A low number of donor-specific cytotoxic T lymphocytes
identifies patients in whom the immunosuppressive load can be safely reduced," the investigators concluded.
Vaccinia virus-specific CD8+ cytotoxic T lymphocytes
Many vaccine peptides have been developed for stimulation of patients' cytotoxic T lymphocytes
to kill cancer cells.
Rotavirus-specific cytotoxic T lymphocytes
appear at the intestinal mucosal surface after rotavirus infection.
Responses such as T cell proliferation (replication of white blood cells in laboratory tests), the production of interferon (produced by lymphocytes in response to a viral infection) and the production of cytotoxic T lymphocytes
(killer T cells) were induced by the vaccine.
The vaccines will employ IDEC's PROVAX(TM) adjuvant to induce cytotoxic T lymphocyte
responses to the tumor-associated antigens.
In in vivo and in vitro tests, Multikine has been shown to be a strong inducer of Natural Killer (NK) cells and cytotoxic T lymphocyte
(CTL) activity, both of which are thought to be important in immune-boosting, anti-cancer responses.
This preclinical data highlights that BGB324, a first-in-class, highly selective small molecule inhibitor of the Axl receptor tyrosine kinase, used in combination with immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1) in mouse carcinoma models showed enhanced tumour clearance, survival and tumour infiltration of cytotoxic T lymphocytes
compared with checkpoint inhibition alone.
IPSCs can also be established from mature cytotoxic T lymphocytes
, thereby allowing cloning and expansion of functional antigen-specific cytotoxic cells that might be useful in cell-based therapy of cancer.
Price DA, O'callaghan CA, Whelan JA, Easterbrook PJ, Phillips RE Cytotoxic T lymphocytes
and viral evolution in primary HIV-1 infection.
When the immune cells known as cytotoxic lymphocytes (including cytotoxic T lymphocytes
and natural killer cells) are activated, "they produce a massive amount of perforin, yet the cells are fine," Voskoboinik said.
Subcutaneous panniculitic T-cell lymphoma is a tumor of cytotoxic T lymphocytes