cytotoxic T lymphocyte

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cytotoxic T lymphocyte

CTL, cytotoxic T cell Immunology A subset of T cells with a CD8 receptor on the surface that recognizes and lyses malignant or virally-infected self cells bearing self, ie 'haplotype restricted', class I MHC molecules. See Helper cells, Perforin, Suppressor cells.


having a deleterious effect upon cells.

cytotoxic antibody
see cytotoxic antibody.
cytotoxic drugs
generally refers to those used in chemotherapy of neoplasms, e.g. cyclophosphamide, vincristine, etc.
cytotoxic T lymphocyte
see T lymphocyte.
References in periodicals archive ?
Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
Memory and distribution of virus-specific cytotoxic T lymphocytes (CTLs) and CTL precursors after rotavirus infection.
There are data on the possibility of the involvement of the DNase activity of T-lymphocytes not only in the DNA fragmentation induced by cytotoxic T lymphocytes (CTL) to target cells, but also in the process of programmed death of type 1 of these cytotoxic cells (CTL).
The product is a 'prime-boost' cancer immunotherapy product aimed to synergistically induce and expand in vivo cytotoxic T lymphocytes targeting NY-ESO-1 - found in a broad set of tumours.
Our data suggest that individuals who were infected with seasonal human influenza A viruses previously or who received seasonal human influenza vaccines may derive benefit, at least in part, from the preexisting cross-reactive memory cytotoxic T lymphocytes to reduce the severity of pdmH1N1 infection even without protective antibodies," said the researchers.
Heterosubtypic immunity to influenza A virus infection requires B cells but not CDS+ cytotoxic T lymphocytes.
ALVAC-HIV induces the proliferation of cytotoxic T lymphocytes and contains genes coding for glycoprotein 120 and other HIV components in a canarypox vector.
Studying a dozen people with HIV, the scientists found that those who progressed quickest to AIDS had relatively few virus-killing immune cells, known as cytotoxic T lymphocytes, that recognize Tat.
The evidence demonstrates that Defibrotide has anti-inflammatory activity because it prevents transendothelial migration of immune effector cells, and it can reduce the chemotherapy-induced antigenicity of endothelial cells towards allogeneic cytotoxic T lymphocytes.
Some of the most promising approaches among therapeutic vaccines prompt cytotoxic T lymphocytes to control HIV infection.
Cytotoxic T lymphocytes, or CTLs, richly deserve their nickname--killer cells.
CytoDyn's CRO, will present Phase I/II data demonstrating the antiviral effects and absence of liver toxicity in individuals who have failed Highly Active Antiretroviral Therapy (HAART) after Cytolin(R) was used to protect CD4+ T lymphocytes from the anti-self, anti-CD4 cytotoxic T lymphocytes that proliferate uniquely in humans infected with HIV.
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