cytotoxic T cell


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cytotoxic T cell

cytotoxic T cell

A CD8+ T lymphocyte that can destroy microorganisms directly through the release of perforin and proteolytic enzymes. These cells are particularly important in the defense against viruses, rejection of allografts, and, possibly, new malignant cells. Synonym: CD8 cell; cytotoxic cel; killer T cell
See also: cell
References in periodicals archive ?
The cells then transport the combination to the cell surface so that cytotoxic T cells can have access to them.
Doherty notes that investigators are now using cytotoxic T cells to rid bone marrow transplants of viral infections and are designing vaccines, including those for AIDS, to generate these virus-killing cells.
Factors responsible for this relative resistance to infection and disease include cytotoxic T cells, neutralizing antibodies, high concentrations of certain chemokines (e.g., RANTES, MIP-1), human leukocyte antigen haplotype, mannose-binding protein, and tumor necrosis factor alpha, C4, and TAP polymorphism (2-4).
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