(21,23) Although the enhancing effect of piperine has been extensively studied in vivo for improvement of oral bioavailability, there are limited in vitro studies on the co-treatment of curcumin with piperine for cytoprotective
effect or cytotoxicity.
Proteins in Inflammation and Resolution during Experimental Gingivitis-A Pilot Study.
While it acts as a cytoprotective
and antioxidant agent (survival) for normal cells, it promotes oxidative damage and apoptosis (cell death) in malignant cells.
[H.sub.2]S is rapidly emerging as a novel lipophilic cytoprotective
signaling molecule with potent antioxidant, anti-inflammatory, and anti-apoptotic features (8,9).
(1-3) At the cutaneous level, melatonin exhibits antioxidant (direct, as a radical scavenger; indirect, through upregulating antioxidant enzymes), anti-inflammatory, photoprotective, tissue regenerative, and cytoprotective
activity, particularly in its capacity to preserve mitochondrial function.
(12) Moreover, several studies have reported antifungal, (13) antioxidative, (14) and cytoprotective
effects of ED.
Alternative to PPI's Sucralfate is widely a cytoprotective
agent and has been listed as an acceptable prophylaxis for stress ulcer by practice guidelines with the caveat of slightly higher rate of clinically signicant gastric bleeding compared with H2 antagonists9,10.
The bioengineered enzyme works by selectively targeting blood clots and safely augmenting the body's own natural antithrombotic, thrombolytic and cytoprotective
As a thiol-based cytoprotective
agent, it is used for prophylactic treatment in cyclophosphamide-induced hemorrhagic cystitis.
Activated Nrf2 binds to ARE sequences located in the promoters of many cytoprotective
and antioxidant genes, the induction of which leads to increased detoxification and antioxidant potential.
and platelet, has several physiological roles including membrane stabilization, osmoregulation and cytoprotective
effects, antioxidant and anti-inflammatory actions as well as modulation of intracellular calcium concentration and ion channel function.
It improves and activates the transcription of over 500 genes in the human genome, most of which have cytoprotective
functions, including three genes that encode enzymes required for the synthesis of reduced glutathione, one of our body's most important antioxidants.