inclusion bodies

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in·clu·sion bod·ies

distinctive structures frequently formed in the nucleus or cytoplasm (occasionally in both locations) in cells infected with certain filtrable viruses; may be demonstrated by means of various stains, especially Mann eosin methylene blue or Giemsa techniques and visible by light microscopy. Nuclear inclusion bodies are usually acidophilic and are of two morphologic types: 1) granular, hyaline, or amorphous bodies of various sizes, that is, Cowdry type A inclusion bodies, occurring in such diseases as herpes simplex infection or yellow fever; 2) more circumscribed bodies, frequently with several in the same nucleus (and no reaction in adjacent tissue), that is, the type B bodies, occurring in such diseases as Rift Valley fever and poliomyelitis. Cytoplasmic inclusion bodies may be: 1) acidophilic, relatively large, spheric or ovoid, and somewhat granular, as in variola or vaccinia, rabies, and molluscum contagiosum; 2) basophilic, relatively large, complex combinations of viral and cellular material, as in trachoma, psittacosis, and lymphogranuloma venereum. In some instances, inclusion bodies are known to be infective and probably represent aggregates of virus particles in combination with cellular material, whereas others are apparently not infective and may represent only abnormal products formed by the cell in response to injury.
Farlex Partner Medical Dictionary © Farlex 2012

in·clu·sion bod·ies

(in-klū'zhŭn bod'ēz)
Distinctive structures frequently formed in the nucleus or cytoplasm (occasionally in both locations) in cells infected with various filterable viruses; observed especially in nerve, epithelial, or endothelial cells.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

inclusion bodies

Microscopically visible masses of virus material, or areas of altered staining behaviour, seen within cells in a number of virus infections such as RABIES, herpes infections, papovavirus infections and adenovirus infections.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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B) Cytoplasmic inclusion bodies (arrows) in infected Vero cells (hematoxylin and eosin stain, original magnification *400).
Novel Orthopoxvirus and Lethal Disease in Cat, Italy
Langerhans cells have cytoplasmic inclusion bodies known as Birbeck granules; a definitive diagnosis requires electron microscopy of Birbeck granules or CD 1 antigenic determinants by immunohistochemistry.
Langerhans cell histiocytosis: temporal bone invasion in an adult
What do the cytoplasmic inclusion bodies found in neutrophilic leukocytes suggest?
A 69-year-old man with long-standing thrombocytopenia
(4) However, because of the high rates of co-infection, a definitive diagnosis of CMV requires identification of CMV intranuclear or cytoplasmic inclusion bodies in transbronchial biopsy specimens (used in our patients) or open lung biopsy specimens.
Nonspecific radiographic manifestations of cytomegalovirus infection in 4 HIV-positive adults--diagnosis through transbronchial biopsy
All comoviruses studied thus far induce the formation of two different types of cytoplasmic inclusion bodies: a) crystalline inclusions of various and unusual shapes composed of viral particles, which stain violet in Azure A and green in the OG combination (Luxol Brilliant Green BL-Calcomine Orange 2 RS), and are frequently observed in glandular hair cells, guard cells and phloem tissue and occasionally in the epidermis and mesophyll; and b) vesiculate-vacuolate inclusions observed in the cytoplasm of epidermal cells which stain green in OG and red to magenta in Azure A (Gibbs and Paul 1970, Kim and Fulton 1972, Kitajima et al.
Inclusion bodies induced by Bean rugose mosaic comovirus seen under light microscopy
Multiple cytoplasmic inclusion bodies were observed in the intestinal smooth-muscle cells of an adult canary from an aviary with a history of high mortality (50%).
Avian Pathol: Circovirus inclusion bodies in intestinal muscle cells of a canary

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