Ten samples were assigned to 2 tracks that included the cytopenia
track and 1 other.
In patients with cytopenia
and/or low-grade MDS, copper dosage can be appropriate.
1RA, refractory anemia; RARS, refractory anemia with ring sideroblasts; RCMD, refractory cytopenia
with multilineage dysplasia; RAEB, refractory anemia with excess blasts.
We studied all patients with cirrhosis with cytopenia
(anemia, leucopenia, and/or thrombocytopenia), admitted in the Institute of Liver & Biliary Sciences, between January 2016 and July 2017, who underwent a bone marrow (BM) aspiration and/or biopsy procedure.
No malignancies developed in any of our patients; however, CVID patients must be monitored for autoimmunity, cytopenia
, and malignancy .
Various terminologies are used to define cytopenia
and its severity.
Metastatic melanoma of the BM presenting with DIC in the absence of widespread metastasis is rare but remains a differential diagnosis in patients presenting with coagulopathy or cytopenia
. Combination immunotherapy should be strongly considered in patients with good performance status, as our patient's excellent response suggests high immunogenicity of the BM, consistent with evolving data on immune checkpoint inhibitors in hematologic malignancies.
Regarding the molecular mechanism, it was found that the defect of CIAS1 or NALP3 gene (on chromosome 1) was a shared gene background in various neonatal autoimmune diseases, including CAPS, FCAS, NOMID, and some types of hematological cytopenia
. Therefore, aberrant functioning of the inflammasome may play an important role in the pathogenesis of autoimmune-mediated fetal/neonatal inflammatory diseases.,,
Patients with MDS present with cytopenias
, or low blood cell counts.
Systemic findings, nephritis, neuropsychiatric disease, and cytopenia
are more common in children than in adults at presentation.
Visceral leishmaniasis may also mimic hematological malignancies, and clinically suspicious patients having cytopenia
, fever, and splenomegaly must be analyzed by at least one serological test specific for leishmaniasis.
On the other hand, pyroptosis is important in the inflammatory process since it can make activated macrophages rapidly release large amounts of cytokines into the extracellular space, and pyroptosis-induced depletion of immune cells is associated with cytopenia
and immune suppression [22-24].