cytopathic effect


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cy·to·path·ic ef·fect

degenerative changes in cells (especially in tissue culture) associated with the multiplication of certain viruses; when, in tissue culture, spread of virus is restricted by an overlay of agar (or other suitable substance) the cytopathic effect may lead to formation of plaque.

cytopathic effect

The characteristic changes which occur in virally-infected cells in tissue culture, which provides a presumptive means of identifying viruses obtained from a clinical specimen—e.g., adenovirus produces grape-like clusters in HEK cells; rhinovirus produces irregular, rounded “dew drop” changes in culture cells; rubella is diagnosed by exclusion, as it interferes with the CPE of other viruses.
References in periodicals archive ?
They were later incubated at 37[degrees]C and scored daily using an inverted microscope for cytopathic effect for 10 days.
Instead, histopathology of specimens taken from the left piriform sinus, left aryepiglottic fold, left vallecula, and left tonsillar pillar demonstrated a viral cytopathic effect and necrosis consistent with HSV infection.
Inhibition of the typical herpes simplex cytopathic effect (CPE) was recorded as the inhibitory effect of the extract.
Then, cells were infected with HSV-1 or 2 (10 TCID50) and incubated at 37 C in 5% CO2 air and observed every day up to three days for cell cytopathic effect (CPE) using a light microscope.
Assays of antiviral activity and cytotoxicity were evaluated by the SRB method using cytopathic effect (CPE) reduction recently reported (Choi et al.
For a marked response, rare, single cancer cells, or small groups of cancer cells/glands with marked cytopathic effect, may be present within a fibrotic stroma.
Cytopathic effect (CPE) is observed in next 24-72 hours, the CPE consists of retraction of the cell membrane from surrounding cells and eventually rounding of the cells with margination of nuclear chromatin (Davies and Mbugwa, 1985).
Cells were incubated in their respective media supplemented with 2 per cent FBS at 37[degrees]C in incubator until cytopathic effect (CPE) was observed (3 days for measles).
The cytopathic effect of CMV is most notable in infected endothelial cells found within granulation tissue in the ulcer base.
These tests can be general tests where the inoculated cells are observed for cytopathic effect due to virus infection.
no cytopathic effect in cell culture was identified after 10 days' incubation).
A cytopathic effect was observed, which demonstrated viability and infectivity of the virus.