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Related to cytomegalovirus mononucleosis: infectious mononucleosis, Epstein barr virus mononucleosis


excess of monocytes in the blood; frequently used alone to refer to infectious mononucleosis.
cytomegalovirus mononucleosis a syndrome similar to infectious mononucleosis but caused by infection with cytomegalovirus.
infectious mononucleosis an acute infectious disease that causes changes in the leukocytes; it is caused by the Epstein-Barr virus and is usually transmitted by direct oral contact (which is why it is sometimes called the “kissing disease”). It occurs more frequently in the spring and affects primarily children and young adults. Although epidemics have been reported, some authorities doubt that the disorder has been the same in all instances. Called also glandular fever.
Symptoms. Generally, after an incubation period of one week to several weeks, headache, sore throat, fatigue, severe weakness, and influenzalike symptoms occur. Skin rashes may also occur. Diagnosis can be confirmed by the finding of a marked increase in the number of monocytes in the patient's blood. Besides these normal cells of the lymphocyte class, there is often an increase in atypical lymphocytes. Another diagnostic test that indicates mononucleosis is the paul-bunnell test, which demonstrates the presence of certain antibodies capable of causing clumping of cells in a sample of sheep's blood.

In about 8 to 10 per cent of all cases, the liver is involved and jaundice occurs, resulting in a condition that resembles infectious hepatitis. In rare cases, the heart, lungs, and central nervous system may also be affected. The spleen may become enlarged; one of the complications, serious but rare, is rupture of the spleen. The lymph nodes and spleen may both remain enlarged for sometime after other symptoms have disappeared.
Treatment. Treatment is chiefly symptomatic. Rest is especially important in the early stages of the disease, or later if the liver is involved. There is as yet no specific treatment for mononucleosis, and no immunization is available. Headache and sore throat may be relieved by aspirin and gargles. Although the more obvious symptoms may disappear after a period of rest, sufficient rest and curtailed activities must be maintained in order to improve the patient's severely weakened condition and prevent recurrence. There is often mental as well as physical fatigue, especially among students, and in these cases some mental depression may accompany convalescence.

Chronic, lingering infectious mononucleosis occurs in some patients. They experience profound fatigue, low-grade fever, swollen lymph glands, a sore throat, and aching muscles and joints. These symptoms can persist for months or years, and often cause the patient to be labeled neurotic because of a lack of objective evidence of disease. The condition can be definitively diagnosed by blood testing for antibodies to the Epstein-Barr virus. Unfortunately, diagnosis can provide psychological relief only, as there is no effective treatment or cure for the disorder.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Presence of abnormally large numbers of mononuclear leukocytes in the circulating blood, especially with reference to forms that are not normal.
Farlex Partner Medical Dictionary © Farlex 2012


(mŏn′ō-no͞o′klē-ō′sĭs, -nyo͞o-)
1. The presence of an abnormally large number of white blood cells with single nuclei in the bloodstream.
2. Infectious mononucleosis.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


See Infectious mononucleosis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


Presence of abnormally large numbers of mononuclear leukocytes in the circulating blood, especially with reference to forms that are not normal.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


Any condition featuring an abnormal number of monocytes in the blood. See also GLANDULAR FEVER (infectious mononucleosis).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005


An infectious disease with symptoms that include severe fatigue, fever, sore throat, and swollen lymph nodes in the neck and armpits. Also called "mono."
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

Patient discussion about mononucleosis

Q. What is the connection between fibromyalgia and glandular fever? How can you protect yourself from this viral infection?

A. There is a notion that some of the autoimmune conditions are caused by a trigger in the shape of a virus. Like the papiloma virus and cervical cancer. So there might be a connection between fibromyalgia and a virus.

Q. can mono kill you if it gets to the liver? otherwise known as the kissing desiaes.

A. It can be fatal, not necessarily through infecting the liver but through rupture of enlarged spleen or obstruction of the throat, or through the development of cancer (e.g. lymphoma) later in life.

However, these complications are very rare, and most people recover from the disease without major complications.

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More discussions about mononucleosis
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