According to these evidences, a significant reduction of [CD56.sup.dim] NK cells and a concomitant loss of NK cell function in terms of cytolytic
activity were also found in patients with unstable coronary artery disease (CAD) .
Litjens, "Expansion of cytolytic
[CD4.sup.+] CD28- T cells in end-stage renal disease," Kidney International, vol.
Many antigenic peptides presented to [CD8.sup.+] cytolytic
T lymphocytes by HLA class I molecules have been identified in proteins MAGE-A1, -A2, -A3, -A4, -A6, -A10, and -A12 [for a review, see Ref.
activity of Limulus plasma proteins was assayed with sheep red blood cells as described previously (3).
They subsequently showed that Hsp70-derived 14-mer peptide (TKD) in combination with IL-2 enhances the cytolytic
activity of resting NK cells against tumor cells presenting Hsp70 on their cell membrane .
We suggest that Busycon has a cytolytic
system in the plasma that functions to destroy invading pathogens.
FACS analysis demonstrated a slight but significant (p = 0.04) increase in cytolytic
activity of spleen cells from 2 of 3 vaccinated mice against Neuro 2a targets when compared with spleen cells from unvaccinated controls.
activity of the secretion was assayed by the lysis of sheep erythrocytes using methods described previously (2).
Martinez et al., "Recognition and killing of brain tumor stem-like initiating cells by [CD8.sup.+] cytolytic
T cells," Cancer Research, vol.
destruction of invading pathogens by proteins of the plasma is an important immune defense strategy of higher animals.
These CD[8.sup.+] T cells developed cytolytic
activities when cultured with different HLA-E haplotyped endothelial cell cultures independently of the HLA-E allele.
These studies, described in "Amphiphile-modifications target mKRAS-antigen and adjuvant to lymph nodes and enable polyfunctional mKRAS-specific immune responses with potent cytolytic
activity," co-authored by Peter DeMuth, PhD., Elicio vice president of Research, will be presented at the Immuno-Oncology Summit in Boston on August 8th, 2019.