faecium groups; BIO+, biofilm-positive; BIO-, biofilm-negative; n, number of strains; acm, collagen adhesin; gelE, gelatinase; esp, enterococcal surface protein; hyl, hyaluronidase; efa, endocarditis antigen; cyl,
cytolysin; AMP, ampicillin; IMP, imipenem; GN, gentamicin; S, streptomycin; VA, vancomycin; TEI, teicoplanin; TG, tigecycline; LZD, linezolid; *lack of differences between groups.
Parker, Structure of a Cholesterol-Binding, Thiol-Activated
Cytolysin and a Model of its Membrane Form, Cell, 89, 685 (1997).
Helicobacter pylori pore-forming
cytolysin orthologue TlyA possesses in vitro hemolytic activity and has a role in colonization of the gastric mucosa.
faecalis; gelE, extracellular metalloendopeptidase (gelatinase) for both species; hyl, hyaluronidase for both species; cylA, activation of
cytolysin (hemolysin/class I.
Menestrina (1996) Mechanism of membrane permeabilization by sticholysin I, a
cytolysin isolated from the venom of the sea anemone Stichodactyla helianthus.
Others such as
cytolysin [7], enterolysin A [8], gelatinase [9], hyaluronidase, Zn-metalloendopeptidase, enhanced expression of pheromone (Eep) [10], and adhesion-associated protein EfaA (E.
Listeriolysin O is a 529 amino acid protein that is a member of the cholesterol-dependent
cytolysin (CDC) family of proteins [4].
It produces a toxin (vaginolysin), which is a cholesterol dependent
cytolysin (CDC).
Selected Efs and Efm isolates were evaluatedfor the expression of three virulencefactors: gelatinase,
cytolysin (hemolysin), and bacteriocin.
One of the three S milleri subtypes, S intermedius, has been shown to produce a human-specific
cytolysin called intermedilysin.
Low density lipoprotein inactivates Vibrio vulnificus
cytolysin through the oligomerization of toxin monomer.
In addition to the core
cytolysin domain involved in assembly and membrane-spanning, VCC has an N-terminal pro-domain that locks the oligomerization domain in an inactive conformation and two contiguous lectin domains at the C-terminus (13).
