faecium groups; BIO+, biofilm-positive; BIO-, biofilm-negative; n, number of strains; acm, collagen adhesin; gelE, gelatinase; esp, enterococcal surface protein; hyl, hyaluronidase; efa, endocarditis antigen; cyl, cytolysin
; AMP, ampicillin; IMP, imipenem; GN, gentamicin; S, streptomycin; VA, vancomycin; TEI, teicoplanin; TG, tigecycline; LZD, linezolid; *lack of differences between groups.
Parker, Structure of a Cholesterol-Binding, Thiol-Activated Cytolysin
and a Model of its Membrane Form, Cell, 89, 685 (1997).
Helicobacter pylori pore-forming cytolysin
orthologue TlyA possesses in vitro hemolytic activity and has a role in colonization of the gastric mucosa.
faecalis; gelE, extracellular metalloendopeptidase (gelatinase) for both species; hyl, hyaluronidase for both species; cylA, activation of cytolysin
Menestrina (1996) Mechanism of membrane permeabilization by sticholysin I, a cytolysin
isolated from the venom of the sea anemone Stichodactyla helianthus.
Others such as cytolysin
, enterolysin A , gelatinase , hyaluronidase, Zn-metalloendopeptidase, enhanced expression of pheromone (Eep) , and adhesion-associated protein EfaA (E.
Listeriolysin O is a 529 amino acid protein that is a member of the cholesterol-dependent cytolysin
(CDC) family of proteins .
It produces a toxin (vaginolysin), which is a cholesterol dependent cytolysin
Selected Efs and Efm isolates were evaluatedfor the expression of three virulencefactors: gelatinase, cytolysin
(hemolysin), and bacteriocin.
One of the three S milleri subtypes, S intermedius, has been shown to produce a human-specific cytolysin
Low density lipoprotein inactivates Vibrio vulnificus cytolysin
through the oligomerization of toxin monomer.
In addition to the core cytolysin
domain involved in assembly and membrane-spanning, VCC has an N-terminal pro-domain that locks the oligomerization domain in an inactive conformation and two contiguous lectin domains at the C-terminus (13).