KRT8

(redirected from cytokeratin-8)

KRT8

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin that heteropolymerises to form intermediate filaments in epithelial cell cytoplasm. The KRT 8 typically dimerises with KRT 18 to form an intermediate filament in simple single-layered epithelial cells. KRT8  plays a role in maintaining cellular structural integrity, in signal
transduction and cell differentiation.

Molecular pathology
KRT8 mutations cause cryptogenic cirrhosis.
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Cystic epithelium lining the lumina was stained with cytokeratin-19 and cytokeratin-8. Some of vacuolated cells were stained with cytokeratin-19 (Figure 3, 4).
Misago and Narisawa (2) reported undifferentiated basaloid cells and vacuolated cells are stained with cytokeratin-8, 18 and 19 and vacuolated cells are stained with cytokeratin-7, 10 and 17 in sebaceoma (11).