KRT18

(redirected from cytokeratin-18)

KRT18

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein. Together with its filament partner keratin 8, they are the most commonly expressed of all intermediate filaments, and found in tissues lined by single layer epithelia.
 
Molecular pathology
KRT18 mutations are associated with cryptogenic cirrhosis.
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References in periodicals archive ?
Maternal and fetal serum levels of caspase-cleaved fragments of cytokeratin-18 in intrahepatic cholestasis of pregnancy.
Additional biomarkers associated with NASH and liver damaged were also reduced by IMM-124E including aspartate transaminase and cytokeratin-18. The primary objective of the study was to evaluate the safety and efficacy of IMM-124E, at two oral dosage levels as compared with a placebo and provide proof of concept in human subjects for its unique Mechanism of Action.
McCullough, "Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study," Hepatology, vol.
Gonzalez-Rivero et al., "Serum levels of caspase-cleaved cytokeratin-18 and mortality are associated in severe septic patients: pilot study," PLoS One, vol.
In the immunohistochemical analysis, the epithelial membrane antigen, pancytokeratin, was diffuse positive and cytokeratin-18 was positive (Figure 3), NSE was focal positive (Figure 4).
Wong et al., "Systematic reviewwith meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease--the role of transient elastography and plasma cytokeratin-18 fragments," Alimentary Pharmacology and Therapeutics, vol.
Subsequently, the sections were incubated with mouse anti-rat [alpha]-smooth muscle actin ([alpha]-SMA; 1: 100 dilution, Santa Cruz Biotechnology, Dallas, TX, USA), tyrosine kinase receptor (C-kit; 1: 100 dilution, Abcam, UK), cytokeratin-18 (CK-18; 1:50 dilution, Abcam, UK), and matrix metalloproteinase-9 antibodies (MMP-9; 1 : 100 dilution, Abcam) at 4[degrees]C overnight.
To detect DNA fragmentation in epithelial cells in lung tissue M30 (Cytokeratin-18) and to evaluate apoptosis in kidney tissue active caspase-3 immunohistochemistry was applied to the paraffin sections.
Plasma levels of caspase-generated cytokeratin-18 fragments, a marker of hepatocyte apoptosis, have also been used to identify NASH (non alcoholic steatohepatitis).
The ELISA measures the accumulation of a caspase-cleaved fragment of cytokeratin-18 (CK18-Asp396) in cells and tissue culture medium over time (Kramer et al., 2004).