KRT1

(redirected from cytokeratin-1)

KRT1

A gene on chromosome  12q13.13 that encodes a type-II cytokeratin that is specifically co-expressed in the spinous and granular layers of the epidermis with KRT10.
 
Molecular pathology
KRT1 mutations are associated with bullous congenital ichthyosiform erythroderma, ichthyosis hystrix and Curth-Macklin type.
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References in periodicals archive ?
In a study of cytokeratins in a case of rippled-patterned sebaceoma, cytokeratin-1 negativity and cytokeratin-14 positivity in tumor nests were linked to the presence of undifferentiated epithelial cells.