KRT8

(redirected from cytokeratin 8)

KRT8

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin that heteropolymerises to form intermediate filaments in epithelial cell cytoplasm. The KRT 8 typically dimerises with KRT 18 to form an intermediate filament in simple single-layered epithelial cells. KRT8  plays a role in maintaining cellular structural integrity, in signal
transduction and cell differentiation.

Molecular pathology
KRT8 mutations cause cryptogenic cirrhosis.
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Immunohistochemically, cells stain positive for antibodies to cytokeratin 8 (CAM 5.2), actin, vimentin and cytokeratin 14 and negative for cytokeratin 18 and 19.
Along with cytokeratin 8, CK-18 is the only cytokeratin found in the hepatocytes [10].
Cytokeratin 8 immunostaining pattern and E-cadherin expression distinguish lobular from ductal breast carcinoma.
Triple-label immunofluorescence for Bax, CYP1A1, and cytokeratin 8/18 localizes the expression of Bax and CYP1A1 in alveolar type II cells (alveolar type II cells contain abundant cytokeratin 8 and cytokeratin 18).
The system uses polyclonal antibodies, and data indicate that they recognize the rod domain of the cytokeratin 8, 18, and 19 fragments; however, the exact structure of the binding epitope is unknown.
Intermediate filament of nucleus pulposus cells is composed of type II collagen, proteoglycan, and Cytokeratin 8 protein [10].
Activated AP-1 regulates type II collagen, proteoglycan, Cytokeratin 8 protein, MAP-1, MAP-2, and MAP-4 by activating collagenase and matrix metalloproteinases (MMPs), thereby regulating cytoskeletal reorganization and remodeling [13].
The correlation of AP-1 with type II collagen, proteoglycan, Cytokeratin 8 protein, MAP-1, MAP-2, and MAP-4 and the correlation of AP-1 with IL-1[beta], TNF-[alpha], IL-6, IL-8, MIP-1, MCP-1, and NO were detected.
(3) After the loading fluid shear stress of 12 dyn x [cm.sup.-2] for 45 minutes, RT-PCR and Western blot assay were used to measure the expression of type II collagen, aggrecan, Cytokeratin 8, MAP-1, MAP-2, and MAP-4.
For HCC biomarkers, alpha-fetoprotein (AFP, 19-fold), plasminogen activator inhibitor-1 (PAI-1, 9-fold), cytokeratin 8 (6-fold), cytokeratin 18 (3-fold) and cytokeratin 19 (11-fold), were dramatically increased in arsenic-induced HCC.
The HCC biomarkers cytokeratin 8 and plasminogen activator inhibitor 1 (PAI-1) were all significantly increased in arsenic-induced HCC, and also higher in arsenic-exposed tumor-surrounding tissues.
The HCC biomarkers [alpha]-fetoprotein, plasminogen activator inhibitor 1 (PAI-1), cytokeratin 8, cytokeratin 18, and cytokeratin 19, as well as the neoplastic progression protein-3, were all significantly increased, consistent with HCC pathobiology and previous findings with arsenic (Liu et al.