KRT7

(redirected from cytokeratin 7)

KRT7

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin specifically expressed in the simple epithelia of internal organs, glands, ducts and blood vessels.
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Immunohistochemically, the tumour cells stained positive for cytokeratin (AE1/AE3), cytokeratin 7, and c-kit (weak staining) and negative for vimentin and CD10 (Fig.
7) Basal cell carcinomas commonly show a high Ki-67 index (>20%) (Figure 2, H), are typically negative for synaptophysin, and usually show luminal cytokeratin 7 expression in the adenoid cystic pattern and cytokeratin 7 negativity in the solid basal cell nests.
Immunohistochemistry showed tumour expression of cytokeratin 7, cytokeratin 20, CA 125, the oestrogen receptor, E--cadherin (CD 324) and TTF1.
6 30 1,000 [1A4] (Variable) CD3 -- Monoclonal [PS1] 6 30 2,000 (Variable) CD20 -- Monoclonal [L26] 25 125 2,000 (Variable) Cytokeratin 7 -- Monoclonal 25 125 3,000 [K72.
The mediastinal tumor samples taken from our patient stained positively for vimentin, muscle-specific actin, and desmin and were negative for cytokeratin AE 1/3, cytokeratin 7, cytokeratin 20, epithelial membrane antigen (EMA), calretinin, S100 protein, melanoma antibody (HMB45), and leukocyte common antigen.
D) Positive staining with cytokeratin 7 (x200) in papillary RCC (arrow), negative staining in oncocytoma (arrowhead).
Immunohistochemical studies showed that the tumor cells in the primary ovarian mass were strongly and diffusely positive for cytokeratin 7 (Figure 2, A) and cytokeratin 8/18, including the spindle cells within the hyalinized and collagenous stroma.
In this case, immunostains for PSAS, prostate-specific acid phosphatase, cytokeratin 7, cytokeratin 20 were negative, while those for chromogranin and synaptophysin were strongly positive - these factors helped in the diagnosis.
2 cocktail, 3 cases; AE1/AE3, 1 case; cytokeratin 7, 1 case) were reviewed if available.
Metastatic breast carcinomas are usually positive for gross cystic disease fluid protein-15 (GCDFP-15), cytokeratin 7, carcinoembryonic antigen, estrogen receptor, and progesterone receptors, and negative for cytokeratin 20.
Immunohistochemical evaluation demonstrated that CEA and cytokeratin 7 were positive, and PSA and cytokeratin 20 were negative.
The antibodies used included prostate-specific antigen (PSA); [alplha]-methylacyl-CoA racemase, high-molecular-weight cytokeratin and p63 protein cocktail (PIN4); cytokeratin 7 (CK7); cytokeratin 20 (CK20); epithelial membrane antigen (EMA); mucin type 1 sialoglycoprotein (MUC1); cluster of differentiation 31/platelet-endothelial cell adhesion molecule 1 (CD31); thyroid transcription factor 1 (TTF1); caudal-related homeobox 2 (CDX2); and Wilms tumor protein 1 (WT1).