KRT20

(redirected from cytokeratin 20)

KRT20

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein that is a major cellular protein of mature enterocytes and goblet cells, and is specifically expressed in gastric and intestinal mucosa.
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Comparative analysis of cytokeratin 15, TDAG51, cytokeratin 20 and androgen receptor in sclerosing adnexal neoplasms and variants of basal cell carcinoma.
In Immunohistochemistry (IHC), the tumour cells showed diffuse strong cytoplasmic positivity for Cytokeratin 20 (CK20).
The cytokeratin 20 immunostain was positive in the surface urothelium and negative in the tumour cells.
reported that the detection of circulating cytokeratin 20 (CK-20)-positive cells by reverse transcription (RT)-PCR in 33.
Cytokeratin 20 (CK20) is a well-known biomarker for detecting circulating tumor cells (CTCs) in the patients with metastatic CRC [19].
1 Immunohistochemically, tumors of ovarian epithelium origin stain positive for cytokeratin 7 (CK7) and stain negative for cytokeratin 20 (CK20), while tumors of appendiceal epithelium origin stain positive for CK20 and stain negative for CK7.
The immunohistochemical studies revealed tumor cell positivity for cytokeratin 19, carcinoembryonic antigen (partial positive), villin, caudal-related homeodomain transcription-2, and Ki67 50%, but studies were negative for TTF-1, cytokeratin 7, cytokeratin 20, and NapsinA.
IHC showed poorly differentiated adenocarcinoma expressing cytokeratin 7 (figure 3) and thyroid transcription factor 1, whereas cytokeratin 20 and smooth muscle actin were negative.
Immunohistochemical analysis was performed employing the avidin-biotin-peroxidase technique, using monoclonal antibodies to CD34, bcl-2, cytokeratin 20 and MIB-1 (all antibodies by DAKO, Glostrup, Denmark).
Immunohistochemistry showed tumour expression of cytokeratin 7, cytokeratin 20, CA 125, the oestrogen receptor, E--cadherin (CD 324) and TTF1.
Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasm : a survey of 435 cases.
Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites.