Expression of cytokeratin 7 is variable and cytokeratin 20
is mostly stained with adenocarcinoma of the bladder.
Analysis of thyroid transcription factor-1 and cytokeratin 20
separates Merkel cell carcinoma from small cell carcinoma of lung.
Results of immunohistochemistry staining were: pan-cytokeratin (+), protein 63 (P63) (+), Sal-like protein 4 (SALL4) (+), CD 99 (+), alpha-fetoprotein (+), glypican (+), vimentin (+), Tiroid transkripsiyon faktor-1 (TTF-1) (-), napsin-A (-), Cluster of Differantiation 30 (CD 30) (-), cytokeratin 20
(-), cytokeratin 20
(-), Epithelial membrane antigen (EMA) (-), Transducin-like enhancer protein 1 (TLE1) (-), and Octamer-binding transcription factor 4 (Oct-4) (-).
Immunohistochemistry study results were negative for thyroid transcription factor-1, cytokeratin 20
, prostatic-specific antigen, and thyroglubilin.
The tumor cells were strongly positive for cytokeratin 7 (CK7), cytokeratin 5/6 (CK5/6), tumor protein 63 (p63), estrogen receptor (ER), progesterone receptor (PR) and were negative for cytokeratin 20
Among the most common markers investigated for this purpose are cytokeratin 20
(CK20) and p53.
Helm, "Cytokeratin 20
: a marker for diagnosing Merkel cell carcinoma," The American Journal of Dermatopathology, vol.
In regard to immunohistochemistry, the tumor cells diffuse positive for cytokeratin 7 and 19 (Figure 5), negative for cytokeratin 20
and synaptophysin, and lacked mCEA and pCEA (Figure 6).
Immunostaining of the ovarian tumor was positive for epithelial membrane antigen, synaptophysin (Figure 1(d)), neuron-specific enolase (NSE) (Figure 1(e)), p16, and cluster of differentiation (CD) 56 and negative for cytokeratin 20
, Wilms Tumor 1, thyroid transcription factor 1, and anti-cytokeratin (CK) antibodies CK18, CK19, and CD99.
Both components were negative for cytokeratin 20
Immunohistochemically, ICC tumor cells were positive for cytokeratin 7 and PTHrP (Figure 3(d)) and negative for cytokeratin 20
, CDX2, and CA19-9.