KRT18

(redirected from cytokeratin 18)

KRT18

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein. Together with its filament partner keratin 8, they are the most commonly expressed of all intermediate filaments, and found in tissues lined by single layer epithelia.
 
Molecular pathology
KRT18 mutations are associated with cryptogenic cirrhosis.
References in periodicals archive ?
Most undifferentiated carcinomas show focal but strong staining for cytokeratins or epithelial membrane antigen, with cytokeratin 18 being the most frequently produced keratin.
M30 antibody detects degraded fragments of cytokeratin 18 (dCK18) in the cytoplasm of a cell undergoing apoptosis and is considered the cytoplasmic end product of apoptosis.
A and B, Photomicrographs showing focal faint cytoplasmic positivity for M30/fragmented cytokeratin 18 immunostain in both crypts and villi of duodenal biopsy specimens from controls.
This assay provides an integrative measure of apoptosis based on the accumulation of a caspase-cleavage product of cytokeratin 18 (ccCK18) in cells and culture medium.
Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18.
16) Cytokeratin 18 is reactive in the physaliphorous cells, a supposed, but questionable, distinction from fetal notochordal tissue (see below).
16) Cytokeratin 18 is variable; in a study of 16 cases, 9 (56.
For HCC biomarkers, alpha-fetoprotein (AFP, 19-fold), plasminogen activator inhibitor-1 (PAI-1, 9-fold), cytokeratin 8 (6-fold), cytokeratin 18 (3-fold) and cytokeratin 19 (11-fold), were dramatically increased in arsenic-induced HCC.
The HCC biomarkers [alpha]-fetoprotein, plasminogen activator inhibitor 1 (PAI-1), cytokeratin 8, cytokeratin 18, and cytokeratin 19, as well as the neoplastic progression protein-3, were all significantly increased, consistent with HCC pathobiology and previous findings with arsenic (Liu et al.
The TPS assay is a monoclonal test specific to the M3-binding region on cytokeratin 18.
20] It is a monoclonal antibody called M30, which recognizes a neoepitope of cytokeratin 18 (CK18) in paraffin-embedded tissue.
10] These cells have been shown to react with cytokeratin 8 (CK8) and cytokeratin 18 (CK18) antibodies, and the cytokeratin immunoreactivity can be variable, depending on the antibody used.