cytogenetics


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Related to cytogenetics: Flow cytometry, molecular genetics

cytogenetics

 [si″to-jĕ-net´iks]
that branch of genetics devoted to the cellular constituents concerned in heredity, i.e., the chromosomes.
clinical cytogenetics the branch of cytogenetics concerned with relations between chromosomal abnormalities and pathologic conditions.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cy·to·ge·net·ics

(sī'tō-jĕ-net'iks),
The branch of genetics concerned with the structure and function of the cell, especially the chromosomes.

Cytogenetics arose as a fusion of 19th-century cytology and 20th-century genetics, which came into being in 1903 with the articulation of the chromosome theory of inheritance. The developing field concerned itself with detailing the behavior of chromosomes and their functional subunits, the genes, during reproduction, and with relating that behavior statistically to characteristics of the resulting cells or animals. Modern molecular cytogenetics involves the microscopic study of chromosomes that have been fixed in mitosis and stained with various agents to delineate characteristic bands. DNA probes can be applied to locate specific gene sequences. Karyotyping is the arrangement of photographs of stained chromosomes in a standard format. Cytogenetic techniques are used to test for inborn errors of metabolism and genomic aberrations such as Down syndrome and to determine sex in cases where anatomy is inconclusive.

Farlex Partner Medical Dictionary © Farlex 2012

cytogenetics

(sī′tō-jə-nĕt′ĭks)
n. (used with a sing. verb)
The branch of genetics that deals with the cellular components, particularly chromosomes, that are associated with heredity.

cy′to·ge·net′ic, cy′to·ge·net′i·cal adj.
cy′to·ge·net′i·cal·ly adv.
cy′to·ge·net′i·cist (-sĭst) n.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

cy·to·ge·net·ics

(sī'tō-jĕ-net'iks)
The branch of genetics concerned with the structure and function of the cell, especially the chromosomes. Modern molecular cytogenetics involves the microscopic study of chromosomes that have been arranged as karyotypes. Individuals can be classified according to characteristic banding patterns that appear when the karyotypes are exposed to some dyes. In addition, DNA probes may be applied to locate specific gene sequences. Cytogenetic techniques are used to test for inborn errors of metabolism, for disorders such as Down syndrome, and to determine sex in cases where anatomy is inconclusive.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

cytogenetics

the study of the inheritance of cells and their chromosomes. Cytogenetic analysis of foetal cells (see AMNIOCENTESIS and CYSTIC FIBROSIS) is used to assess potential risks to the baby.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
The scope of cytogenetics includes several technologies besides fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH), and multicolor FISH.
Patients who did not show adequate yield on cytogenetics were also excluded from the study.
Benslimane, "Cytogenetic survey of 53 Moroccan patients with acute myeloblastic leukemia," Cancer Genetics and Cytogenetics, vol.
This shows the importance of cytogenetics in different cases of leukaemia in clinical oncology.
Many clinical trials use cytogenetic and FISH data to stratify patients according to specific risk factors.
Genetics of Memphis said Poplar Healthcare's expanded menu of molecular testing services, including next generation sequencing of hematologic and solid tumors, is an important extension to clinical cytogenetics. By joining Poplar Healthcare, the company can expand service offerings and help improve patient care.
The global molecular cytogenetics market report provides market size (Revenue USD Million 2014 to 2021), market share and forecasts growth trends (CAGR%, 2017 to 2021).
"Years of study, including research within our own group, the Leukaemia Research Cytogenetics Group, has shown that genetic abnormalities in ALL predict the way in which patients respond to therapy.
Molecular Cytogenetics. FISH was done according to standard procedures and manufacturer's instructions for the following commercially available probes: LSI 13 in 13q14.2 (RB1, Abbott Molecular/Vysis, Mannheim, Germany), LSI IGH/BCL2 (IGH in 14q32; BCL2 in 18q21, Abbott Molecular/Vysis, Mannheim, Germany), SPEC ALK/2q11 (ALK in 2p23, Zytovision GmbH, Bremerhaven, Germany), SPEC p16/CEN9 (p16 in 9p21.3, Zytovision GmbH, Bremerhaven, Germany), SPEC BIRC3/MALT1 (BIRC3 in 11q22.2, MALT1 in 18q21.32, Zytovision, Bremerhaven, Germany), and POSEIDON MLL/MLLT3 (MLL in 11q23.3, MLLT3 in 9p21.3; Kreatech Diagnostics, Amsterdam, Netherland).
Five years later, Dr Connie Clarke launched a cytogenetics services which dealt with chromosomal disorders.
Conventional cytogenetics has a very powerful ability to scan the genome for aberrations that involve both gains and losses of portions of the genome, as well as rearrangements within and among chromosomes.