In fact, although Cordyceps has long been used for cancer treatment in China (Zhou et al., 2009) and the anti-cancer effect of Cordyceps has been confirmed in today's clinical researches (Niwa et al., 2013), the direct cytocidal
effects of Cordyceps are not significant (Zhou et al., 2007).
Cytostatic (TGI, [micro]g/mL) and cytocidal
effects ([LC.sub.50], [micro]g/mL; data in parentheses) for methanolic extracts from the Annonaceae.
On the other hand, T24 cells needed more than 30 minutes of exposure to sterile water to have a cytocidal
This effect was concentration dependent, and the extracts had cytotoxic and cytocidal
Figure 6(b) revealed the cytocidal
nature of AAA towards COLO-205 cells, conferring an irreversible action on the cell cycle, with 30.3 [+ or -] 1.8 and 26.6 [+ or -] 1.4 percent proliferation after 48 hours and after 48 hours of medium replacement, respectively, whereas 18.7 [+ or -] 1.4 and 14.3 [+ or -] 1.7 percent proliferation were seen after 72 hours and after 24 hours of medium replacement treatment at a concentration of 200 [micro]g/mL.
Thus, [C.sub.60]/HP-[beta]-CyD itself had no detectable cytocidal
effect on the tumor tissue in the absence of irradiation.
Another is the cytocidal
process by damage of DNA and mitochondrial ATP through oxidative stress and interaction with SH-enzyme .
PGL-I has been shown to play an important role in downregulating the inflammatory immune response, inhibits dendritic cell maturation and activation, facilitates entry of bacilli into macrophages and SCs, and scavenges potentially cytocidal
oxygen metabolites in vitro, all of which would promote the survival of intracellular bacilli.
Potent membrane-permeabilizing and cytocidal
action of Vibrio cholerae cytolysin on human intestinal cells.
and immunopotentiating effects of relatively low molecular weight products derived from the basidiomycete, Agaricus blazei Murrill.
"ATP assay: ability to distinguish cytostatic from cytocidal
anticancer drug effects".
(24) Neopterin is formed preferentially in response to Th1-type cytokine interferon-[gamma], and, because of its ability to amplify deleterious effects of radicals in various cellular systems, neopterin seems part of the pro-inflammatory and cytocidal
armature of the activated human macrophage.