cytochrome P450


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CYP11A1

A gene on chromosome 15q23-q24 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP11A1 localises to the mitochondrial inner membrane and catalyses the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

cytochrome P450

Abbreviation: CYP
A group of enzymes present in every type of cell in the body except red blood cells and skeletal muscle cells. They are important in metabolizing substances normally present in the body such as steroids, fat-soluble vitamins, fatty acids, prostaglandins, and alkaloids. The P450 enzymes also detoxify drugs and a great number of environmental pollutants, such as carcinogens present in tobacco smoke and charcoal-broiled meat, polychlorinated biphenyls, and dioxin. Specialized types of cytochrome P450 are involved in the synthesis of nitric oxide.
See also: cytochrome
Medical Dictionary, © 2009 Farlex and Partners

cytochrome P450

A family of enzymes responsible for the detoxification and elimination of foreign substances including many drugs by hydroxylation and increasing their solubility. The group has been intensively studied because mutations of the cytochrome P450 gene have been found to be associated with a number of diseases including Addison's disease, liver cancer and Parkinson's disease. Cytochrome P450 can also interfere with drug treatment. Selective inhibitors of aromatase-specific cytochrome P450 have been developed to assist in the treatment of breast cancer.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The elucidation of cytochrome P450 family 1-specific activities at a molecular level is of great importance with regard to novel and potent drug design and drug-drug interactions.
(Cytochrome P450 aromatase 1b)###3'-CGGGTCTCCAGAAATCGGTAGA-5'
The Role of Cytochrome P450 3A5 Enzyme on the Metabolism of Tacrolimus in Rats.
Morrison et al., "Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family," Molecular Biology and Evolution, vol.
Gustafsson, "Cytochrome P450 in the breast and brain: role in tissue-specific activation of xenobiotics," Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.
Potential of decursin to inhibit the human cytochrome P450 2J2 isoform.
Inhibition of human cytochrome P450 activities by kava extract and kavalactones.
3-3) Physicochemical and catalytic properties of partially purified steroid hydroxylating enzyme, cytochrome P450. Figure 2 shows the absolute absorption spectra of our partially purified P450 from bovine adrenocortical mitochondria under various conditions.
Knowing that valproic acid is extensively processed by cytochrome P450 enzymes, the research team added a cytochrome P450 inhibitor to mouse and human liver cells and found that AMPK was no longer activated.
The clinical implications of cytochrome P450 interactions with opioids and strategies for pain management.
Zhou, "Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4," Current Drug Metabolism, vol.

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