cytochrome P-450

cytochrome P-450

Clinical pharmacology A superfamily of heme-containing enzymes–CYPs of the electron transport chain, which have multiple activities, including activation of molecular O2 for incorporation into unactivated hydrocarbons, xenobiotic metabolism, bioremediation, and breakdown of drugs and toxins
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The important among these resistance indicators are microsomal mixedfunction oxygenase, cytochrome P-450 dependent monooxygenase and esterase systems (Vontas et al., 2002).
Phosphine-Induced Alterations in Microsomal Enzymes of a Stored Grain Pest Trogoderma granarium Collected from Godowns of Punjab, Pakistan
The three statins (lovastatin, simvastatin, and atorvastatin) are metabolized by the cytochrome p-450 3A4 (CYP-3A4) isoenzymes, whereas pravastatin is metabolized in the liver by sulfation and fluvastatin is metabolized by the cytochrome 2C9 isoenzyme (CYP-2C9) [8].
Severe Rhabdomyolysis as Complication of Interaction between Atorvastatin and Fusidic Acid in a Patient in Lifelong Antibiotic Prophylaxis: A Dangerous Combination
Siest, "Subcellular distribution of cytochrome P-450 in the brain," Brain Research, vol.
The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain
Itakura, "Cloning, sequencing, and phylogenetic analysis of complementary DNA of novel cytochrome P-450 CYP1A in Japanese eel (Anguilla japonica)," Marine Biotechnology, vol.
Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?
It has been reported that the toxic metabolite of acetaminophen bound covalently to cell macromolecules; NAPQI, the toxic metabolite of acetaminophen was reported to be metabolised by cytochrome P-450 in liver and subsequently detoxified.24
Amelioration of acetaminophen induced hepatotoxicity by methanolic extract of pomegranate peels in rats
Moreover, skin and other organs contain metabolic mechanisms known as Cytochrome P-450. The most intense P-450 in the body is present in the liver, the main metabolic organ; however, skin contains metabolic enzymes as well.
Testing for genotoxicity
The P-glycoprotein efflux pump plays a large role in tacrolimus absorption from the gut and distribution in other tissues, while cytochrome P-450 3A (CYP3A) enzyme is primarily responsible for tacrolimus metabolism [9-11].
High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana
Clopidogrel is a prodrug requiring two major biotransformation steps, cytochrome P-450 (CYP) isoenzymes, transforms prodrug an active metabolite that binds irreversibly to the platelet adenosine 5′-diphosphate (ADP) receptor P2Y12.[sup][10] Several functional polymorphisms have been found with genes encoding CYP isoforms which involve in clopidogrel metabolic activation upstream of P2Y12 (e.g., CYP2C19)[sup][11],[12] but their influence on the pharmacodynamic response to clopidogrel has not been systematically investigated, especially in Chinese people with ACS.
CYP2C19*2 and Other Allelic Variants Affecting Platelet Response to Clopidogrel Tested by Thrombelastography in Patients with Acute Coronary Syndrome
(1975) Purification of cytochrome P-450 from bovine adrenocortical mitochondria by an "Aniline-Sepharose" and the properties.
Functional zonation of the rat adrenal cortex: the development and maintenance
Gilbert, "Ecdysone 20-monooxygenase: Characterization of an insect cytochrome P-450 dependent steroid hydroxylase," Molecular and Cellular Endocrinology, vol.
Effects of quinizarin and five synthesized derivatives on fifth larval instar midgut ecdysone 20-monooxygenase activity of the tobacco hornworm Manduca sexta
Influence of deltamethrin on microsomal cytochrome P-450 activity of susceptible house flies (Musca domestica vicina L.).
Over-expression of Cytochrome P450s in Helicoverpa armigera in Response to Bio-insecticide, Cantharidin
The formulation is designed to gradually and reliably raise serum total 25-hydroxyvitamin D (prohormone) concentrations to targeted levels (at least 30 ng/mL) while avoiding upregulation of CYP24, a cytochrome P-450 enzyme that reduces the PTH lowering potency of current vitamin D supplements.
OPKO Health Inc completes more than 50% enrollment in first Phase 3 trial of Rayaldy in patients with chronic kidney disease and vitamin D insufficiency

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