cytochrome P-450

cytochrome P-450

Etymology: Gk, kytos, cell, chroma, color
a protein involved with extramitochondrial electron transport in the liver and in the metabolism or bioactivation of drugs.

cytochrome P-450

Clinical pharmacology A superfamily of heme-containing enzymes–CYPs of the electron transport chain, which have multiple activities, including activation of molecular O2 for incorporation into unactivated hydrocarbons, xenobiotic metabolism, bioremediation, and breakdown of drugs and toxins
Mentioned in ?
References in periodicals archive ?
After PB treatment, the activities of cytochrome p-450 (CP), aniline hydroxylase (AH), acetanilide hydroxylase (AAH), benzphatamine demethylase (BD), aminopyrine demethylase (APD) and N.
Effect of Inorganic Mercury on Drug Metabolizing Enzymes of Promethazine-Pretreated and Phenobarbitone-Pretreated Male Rabbit
Clopidogrel is a prodrug that requires biotransformation by several hepatic cytochrome P-450 (CYP) isoenzymes including CYP2C19 to become an active metabolite [3].
Simultaneous two-vessel subacute stent thrombosis caused by clopidogrel resistance from CYP2C19 polymorphism
The P-glycoprotein efflux pump plays a large role in tacrolimus absorption from the gut and distribution in other tissues, while cytochrome P-450 3A (CYP3A) enzyme is primarily responsible for tacrolimus metabolism [9-11].
High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana
1975) Purification of cytochrome P-450 from bovine adrenocortical mitochondria by an "Aniline-Sepharose" and the properties.
Functional zonation of the rat adrenal cortex: the development and maintenance
Influence of deltamethrin on microsomal cytochrome P-450 activity of susceptible house flies (Musca domestica vicina L.
Over-expression of Cytochrome P450s in Helicoverpa armigera in Response to Bio-insecticide, Cantharidin
The formulation is designed to gradually and reliably raise serum total 25-hydroxyvitamin D (prohormone) concentrations to targeted levels (at least 30 ng/mL) while avoiding upregulation of CYP24, a cytochrome P-450 enzyme that reduces the PTH lowering potency of current vitamin D supplements.
OPKO Health Inc completes more than 50% enrollment in first Phase 3 trial of Rayaldy in patients with chronic kidney disease and vitamin D insufficiency
Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: an update.
Suicide, depression, and CYP2D6: how are they linked? Suicide risk might be increased in depressed patients who are ultra-rapid metabolizers
Cytochrome P-450 pathway in renal function of normal rats and rats with bilateral ureteral obstruction.
Syndrome de levee d'obstacle : physiopathologie et prise en charge
Levels of messenger ribonucleic acid encoding cholesterol side-chain cleavage cytochrome P-450, 17 alpha-hydroxylase cytochrome P-450, adrenodoxin, and low density lipoprotein receptor in bovine follicles and corpora lutea throughout the ovarian cycle.
Protein profile in corpus luteum during pregnancy in Korean Native Cows
5 times better protection of cytochrome P-450 against oxidative damage than d-alpha-tocopherol.
Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol
Cytochrome p-450 polymorphisms and response to clopidogrel.
Clopidogrel: genotipificacion de CYP2C19
henytoin, phenobarbitone and carbamazepine increase metabolic activity of the cytochrome P-450 complex.
Neurological complications of HIV/AIDS in childhood: the neurological complications of human immunodeficiency virus type 1 (HIV-1)/acquired immunodeficiency disease (AIDS) contribute significantly to the morbidity of HIV infection in the paediatric age group

Medical browser ?
Full browser ?