cytochrome P-450

cytochrome P-450

Etymology: Gk, kytos, cell, chroma, color
a protein involved with extramitochondrial electron transport in the liver and in the metabolism or bioactivation of drugs.

cytochrome P-450

Clinical pharmacology A superfamily of heme-containing enzymes–CYPs of the electron transport chain, which have multiple activities, including activation of molecular O2 for incorporation into unactivated hydrocarbons, xenobiotic metabolism, bioremediation, and breakdown of drugs and toxins
References in periodicals archive ?
Expression and induction of Cytochrome P-450 1A1 and P-450 2D subfamily in the rat glioma C6 cell line.
John's wort, which may have some efficacy for depression, interacts with the cytochrome P-450 enzyme system and can thereby decrease indinavir trough blood levels by 81% and nevirapine levels by 21%.
All 55 participants smoked at baseline, and constituents of cigarette smoke activate the same cytochrome P-450 system enzyme that metabolizes olanzapine (Zyprexa), haloperidol decanoate (Haldol), and fluphenazine decanoate.
Cytochrome P-450 (CYP-450) is a heme-containing enzyme and the isoform CYP3A, accounts for about 60% of the total CYP-450 family.
An article in the September 9, 2004 New England Journal of Medicine reported that patients using the antibiotic erythromycin at the same time as drugs that strongly inhibited cytochrome P-450 3A (CYP3A, an enzyme in the liver that helps remove many drugs from the body) had an increased risk of sudden death from cardiac (heart) causes.
Linoleic acid in the body may manipulate the upregulation and overexpression of COX-2 and, coincidentally, the upregulation of the cytochrome P-450 gene.
The hepatic metabolism of many medications is mediated by certain cytochrome P-450 enzymes, and the antidepressants fluvoxamine and nefazodone interfere with certain P-450 enzymes.
Gittleman explains that Phase One stimulates the cytochrome P-450 enzymes needed to trap toxins for oxidation.
At the end of the 4 weeks, the researchers killed the fish and extracted their cytochrome P-450 enzymes, which break down chemicals.
Myopathy should be considered in any patient with diffuse myalgias, muscle tenderness or weakness, and/or marked elevation of creatine phosphokinase (CPK), which may be more frequent when co-administered with drugs that inhibit the cytochrome P-450 metabolizing enzyme system.
Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics
P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies.