cytochrome P-450

cytochrome P-450

Etymology: Gk, kytos, cell, chroma, color
a protein involved with extramitochondrial electron transport in the liver and in the metabolism or bioactivation of drugs.

cytochrome P-450

Clinical pharmacology A superfamily of heme-containing enzymes–CYPs of the electron transport chain, which have multiple activities, including activation of molecular O2 for incorporation into unactivated hydrocarbons, xenobiotic metabolism, bioremediation, and breakdown of drugs and toxins
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Expression and induction of Cytochrome P-450 1A1 and P-450 2D subfamily in the rat glioma C6 cell line.
Activity of cytochrome P-450 in Xenopus laevis embryos as determined by modified enzyme assay
John's wort, which may have some efficacy for depression, interacts with the cytochrome P-450 enzyme system and can thereby decrease indinavir trough blood levels by 81% and nevirapine levels by 21%.
Don't miss HIV patients' alternative medicine use
All 55 participants smoked at baseline, and constituents of cigarette smoke activate the same cytochrome P-450 system enzyme that metabolizes olanzapine (Zyprexa), haloperidol decanoate (Haldol), and fluphenazine decanoate.
Antipsychotics' effects differ in substance abusers: activation of cytochrome P-450 system by cigarette smoke appears to play a role in drug metabolism
Cytochrome P-450 (CYP-450) is a heme-containing enzyme and the isoform CYP3A, accounts for about 60% of the total CYP-450 family.
Ethnicity influences the distribution of cytochrome P450 3a4 gene polymorphism
An article in the September 9, 2004 New England Journal of Medicine reported that patients using the antibiotic erythromycin at the same time as drugs that strongly inhibited cytochrome P-450 3A (CYP3A, an enzyme in the liver that helps remove many drugs from the body) had an increased risk of sudden death from cardiac (heart) causes.
Warning against using erythromycin (even orally) while using protease inhibitors or certain other drugs
Linoleic acid in the body may manipulate the upregulation and overexpression of COX-2 and, coincidentally, the upregulation of the cytochrome P-450 gene.
Regular NSAID use tied to lower risk of breast Ca: Ibuprofen associated with 49% risk reduction after 10 years in older women: women's health initiative
The hepatic metabolism of many medications is mediated by certain cytochrome P-450 enzymes, and the antidepressants fluvoxamine and nefazodone interfere with certain P-450 enzymes.
Psychiatric manifestations of medications commonly prescribed in otolaryngology
Gittleman explains that Phase One stimulates the cytochrome P-450 enzymes needed to trap toxins for oxidation.
Spring Clean Your Body
At the end of the 4 weeks, the researchers killed the fish and extracted their cytochrome P-450 enzymes, which break down chemicals.
Rogue algae may harm Mediterranean fish
Myopathy should be considered in any patient with diffuse myalgias, muscle tenderness or weakness, and/or marked elevation of creatine phosphokinase (CPK), which may be more frequent when co-administered with drugs that inhibit the cytochrome P-450 metabolizing enzyme system.
TRIAL SHOWS LIPID-LOWERING HAS CARDIOVASCULAR BENEFIT
Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics
Research and Markets: Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology
P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies.
Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from Fructus Schisandrae chinensis

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