cytochrome P-450

cytochrome P-450

Etymology: Gk, kytos, cell, chroma, color
a protein involved with extramitochondrial electron transport in the liver and in the metabolism or bioactivation of drugs.

cytochrome P-450

Clinical pharmacology A superfamily of heme-containing enzymes–CYPs of the electron transport chain, which have multiple activities, including activation of molecular O2 for incorporation into unactivated hydrocarbons, xenobiotic metabolism, bioremediation, and breakdown of drugs and toxins
References in periodicals archive ?
After PB treatment, the activities of cytochrome p-450 (CP), aniline hydroxylase (AH), acetanilide hydroxylase (AAH), benzphatamine demethylase (BD), aminopyrine demethylase (APD) and N.
Clopidogrel is a prodrug that requires biotransformation by several hepatic cytochrome P-450 (CYP) isoenzymes including CYP2C19 to become an active metabolite [3].
The P-glycoprotein efflux pump plays a large role in tacrolimus absorption from the gut and distribution in other tissues, while cytochrome P-450 3A (CYP3A) enzyme is primarily responsible for tacrolimus metabolism [9-11].
1975) Purification of cytochrome P-450 from bovine adrenocortical mitochondria by an "Aniline-Sepharose" and the properties.
Influence of deltamethrin on microsomal cytochrome P-450 activity of susceptible house flies (Musca domestica vicina L.
The formulation is designed to gradually and reliably raise serum total 25-hydroxyvitamin D (prohormone) concentrations to targeted levels (at least 30 ng/mL) while avoiding upregulation of CYP24, a cytochrome P-450 enzyme that reduces the PTH lowering potency of current vitamin D supplements.
Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: an update.
Cytochrome P-450 pathway in renal function of normal rats and rats with bilateral ureteral obstruction.
Levels of messenger ribonucleic acid encoding cholesterol side-chain cleavage cytochrome P-450, 17 alpha-hydroxylase cytochrome P-450, adrenodoxin, and low density lipoprotein receptor in bovine follicles and corpora lutea throughout the ovarian cycle.
5 times better protection of cytochrome P-450 against oxidative damage than d-alpha-tocopherol.
Cytochrome p-450 polymorphisms and response to clopidogrel.