The important among these resistance indicators are microsomal mixedfunction oxygenase,
cytochrome P-450 dependent monooxygenase and esterase systems (Vontas et al., 2002).
The three statins (lovastatin, simvastatin, and atorvastatin) are metabolized by the
cytochrome p-450 3A4 (CYP-3A4) isoenzymes, whereas pravastatin is metabolized in the liver by sulfation and fluvastatin is metabolized by the cytochrome 2C9 isoenzyme (CYP-2C9) [8].
Siest, "Subcellular distribution of
cytochrome P-450 in the brain," Brain Research, vol.
Itakura, "Cloning, sequencing, and phylogenetic analysis of complementary DNA of novel
cytochrome P-450 CYP1A in Japanese eel (Anguilla japonica)," Marine Biotechnology, vol.
It has been reported that the toxic metabolite of acetaminophen bound covalently to cell macromolecules; NAPQI, the toxic metabolite of acetaminophen was reported to be metabolised by
cytochrome P-450 in liver and subsequently detoxified.24
Moreover, skin and other organs contain metabolic mechanisms known as
Cytochrome P-450. The most intense P-450 in the body is present in the liver, the main metabolic organ; however, skin contains metabolic enzymes as well.
The P-glycoprotein efflux pump plays a large role in tacrolimus absorption from the gut and distribution in other tissues, while
cytochrome P-450 3A (CYP3A) enzyme is primarily responsible for tacrolimus metabolism [9-11].
Clopidogrel is a prodrug requiring two major biotransformation steps,
cytochrome P-450 (CYP) isoenzymes, transforms prodrug an active metabolite that binds irreversibly to the platelet adenosine 5′-diphosphate (ADP) receptor P2Y12.[sup][10] Several functional polymorphisms have been found with genes encoding CYP isoforms which involve in clopidogrel metabolic activation upstream of P2Y12 (e.g., CYP2C19)[sup][11],[12] but their influence on the pharmacodynamic response to clopidogrel has not been systematically investigated, especially in Chinese people with ACS.
(1975) Purification of
cytochrome P-450 from bovine adrenocortical mitochondria by an "Aniline-Sepharose" and the properties.
Gilbert, "Ecdysone 20-monooxygenase: Characterization of an insect
cytochrome P-450 dependent steroid hydroxylase," Molecular and Cellular Endocrinology, vol.
Influence of deltamethrin on microsomal
cytochrome P-450 activity of susceptible house flies (Musca domestica vicina L.).
The formulation is designed to gradually and reliably raise serum total 25-hydroxyvitamin D (prohormone) concentrations to targeted levels (at least 30 ng/mL) while avoiding upregulation of CYP24, a
cytochrome P-450 enzyme that reduces the PTH lowering potency of current vitamin D supplements.