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Pertaining to cytoarchitecture.
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The final phase of the uterotrophic response coincides with the induction of a battery of genes involved in the cytoarchitectural remodeling of proliferating uterine cells, thus providing a further link between phenotypic and gene expression changes (Figure 7A).
We plan to repeat this process in a sample of brains so that we can quantify cytoarchitectural variability," said Dr.
Misdraji et al (15) later analyzed the histologic features of 107 appendiceal mucinous tumors, which they classified as either low- or high-grade based on cytoarchitectural features.
3,9) Adenomas can also be classified by their cytoarchitectural resemblance to the different parts of the gastrointestinal tract as pyloric gland adenoma, intestinal-type adenoma, and biliary-type adenoma.
Following are important features to be cognizant of: (1) virtually any bone can be affected; (2) it commonly involves the spine, where it has a strong propensity to involve the dorsal vertebral elements as opposed to the body; (3) it can sometimes show locally aggressive growth, which correlates mostly with surgical resectability and possibly with specific histologic features such as prominent epithelioid cell morphology ("aggressive osteoblastoma"); (4) other benign tumors such as osteoid osteoma, aneurysmal bone cyst, giant cell tumor of bone, and sino-orbital osteoma can mimic it histologically; and (5) distinguishing it from osteoblastoma-like osteosarcoma, on the basis of careful evaluation of sometimes subtle cytoarchitectural features, is essential to avoid a misdiagnosis.
Such exceptions include tumors with the typical cytoarchitectural features but which (1) are completely inert to immunoperoxidase stains probably because of fixation artifact; (2) are found to be negative because of sampling issues, such as small endoscopic biopsies with adequate internal controls for others antigens; (3) have ceased to express CD117 because of some form of clonal evolution; or (4) belong to the small percentage of tumors that lack either KIT mutations or KIT overexpression.
Moderate and poorly differentiated angiosarcomas have very heterogeneous cytoarchitectural features.