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Related to cytidine: Cytidine deaminase

cyt·i·dine (C, Cyd),

A major component of ribonucleic acids.
Farlex Partner Medical Dictionary © Farlex 2012


A nucleoside, C9H13N3O5, composed of cytosine and ribose.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


(C, Cyd) (sī'ti-dēn)
A major component of ribonucleic acids.
Synonym(s): cytosine ribonucleoside.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Decitabine is an azanucleoside (AZN), a pyrimidine analogue of cytidine. Cancer cells often exhibit severely altered chromatin structure and methylation patterns leading to promoter hypermethylation and silencing of key tumor suppressor genes.
Niedobitek, "Activation-induced cytidine deaminase (AID) is expressed in normal spermatogenesis but only infrequently in testicular germ cell tumours," Journal of Pathology, vol.
Blomberg, "Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase," Journal of Immunology, vol.
Jankovic et al., "MicroRNA155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation," Immunity, vol.
Abbreviations: AID: activation-induced cytidine deaminase; ASPP2: apoptosis-stimulating protein of p53 2; CagA: Cytotoxin-associated gene A; CBS: C-terminal binding sequence; CM: CagA multimerization; [CM.sup.AmI]: Amerindian type-I CM; [CM.sup.AmII]: Amerindian type-II CM; [CM.sup.E]: East Asian CM; [CM.sup.W]: Western CM; CSK: C-terminal Src kinase; EBV: Epstein-Barr virus; EMT: epithelial-to-mesenchymal transition; EPIYA: GluPro-Ile-Tyr-Ala; GAB: Grb2-associated binder; H.
(4) Immunoglobulin diversification based on the "somatic hypermutation" (SHM) process, which is regulated by the MutS[alpha]-MutL[alpha] complex, in combination with two other proteins, AID (activation-induced cytidine deaminase) and Pol[mu] (DNA Polymerase "error-prone") [40]; in particular, MutSa deficiency is associated with neoplastic transformation of T lymphocytes [41]
Cytidine, 5-methylcytidine, BIS-TRIS propane, tris(hydroxymethyl)aminomethane (TRIS), [H.sub.3]P[O.sub.4], HCl, formic acid, acetonitrile, and deoxyribonucleic acid from calf thymus were purchased from Sigma-Aldrich, Italia (Milan, Italy).
It is also interesting to note that EBV infection of B cells upregulates the expression of enzymes like cytidine deaminase expression, an essential mediator in the process of somatic hypermutation [30].
Therefore, although these agents have been known for a long time, only two inhibitors of DNA methyltransferases, 5-azacytidine (Vidaza) and 5-aza-2-deoxycytidine (decitabine), a cytidine analog, with better specificity, remarkable inhibition of DNA methylation, and less toxic effects than 5-azacytidine, have already been approved by the FDA as effective drugs for treatment of myelodysplastic syndromes [12, 113].
Meanwhile, all patients received nasal tube of oxygen inhalation and conventional treatment with regulating water and electrolytes, maintaining stable blood pressure and blood glucose, and injecting cytidine diphosphate choline (CDPC) and vitamin B.
To date, more than 10 nucleosides, nucleobases, and their related compounds including adenine, adenosine, cytosine, cytidine, uridine, guanine, guanosine, hypoxanthine, vernine, thymidine, cordycepin, and 2',-deoxyuridine have been isolated from O.
Michelessi et al., "Cytidine 51-diphosphocholine (Citicoline) in glaucoma: Rationale of its use, current evidence and future perspectives," International Journal of Molecular Sciences, vol.