cytarabine


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cytarabine

 [si-tar´ah-bēn]
an antimetaboliteantineoplastic agent that inhibits DNA polymerase and thus inhibits DNA synthesis during a specific phase of the cell cycle. Administered intravenously to treat acute myelogenous and other types of leukemia. It is also injected intrathecally to treat meningitis associated with leukemia or lymphoma. Called also cytosine arabinoside.

cytarabine

/cy·tar·a·bine/ (ara-C) (si-tar´ah-bēn) an antimetabolite that inhibits DNA synthesis and hence has antineoplastic properties; used in the treatment of acute myelogenous and other types of leukemia and of meningitis associated with leukemia or lymphoma.

cytarabine

(sī-tăr′ə-bēn′)
n.
A cytotoxic compound that inhibits DNA synthesis and is used as a chemotherapeutic agent, usually in combination with other drugs, in the treatment of certain types of leukemia.

cytarabine

[siter′əbēn]
an antineoplastic agent. Also called arabinosylcytosine, ARA-C, cytosine arabinoside.
indications It is prescribed in the treatment of acute and chronic myelocytic leukemia, acute lymphocytic leukemia, and erythroleukemia.
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects The most serious adverse reactions are bone marrow depression, stomatitis, phlebitis, liver toxicity, fever, and GI disturbances.

cytarabine

AraC, cytosine arabinoside Oncology An antimetabolite analogue of deoxycytidine, used synergistically with antifolates, alkylating agents, and cis-platinum to treat AML Pharmacokinetics Poorly absorbed–±20% absorbed orally, better IV; T1 ⁄ 2, ±2.5 hrs; 90% metabolized to the inactive arabinosyl uracil Side effects N&V, myelosuppression; in high doses, cerebral dysfunction, ataxia

cytarabine

An antimetabolite drug used in the treatment of acute LEUKAEMIA. It is a purine antagonist (see PURINES) and acts by depriving cells of essential metabolic substances. It causes sickness and vomiting, peptic ulcers and depression of bone marrow blood formation. The drug is on the WHO official list. A brand name is Cytosar.

cytarabine

an antimetabolite that inhibits DNA synthesis, and hence has antineoplastic and antiviral properties. Called also cytosine arabinoside, arabinosyl cytosine, ara-C.
References in periodicals archive ?
CLAG-M is a salvage chemotherapy regimen consisting of cladribine, cytarabine, filgrastim and mitoxantrone that has become the standard of care at many institutions across the U.
Cytarabine is a pyrimidine analog which enters into the cells through a carrier process and then converted to its active compound, aracytidine triphosphate.
In this study, ATR-FTIR spectroscopy was employed to investigate the possible intermolecular interaction of Cytarabine with deacetylated chitosan and tripolyphosphate in the resulting physical blends and crosslinked nanoparticulate system.
The primary objectives of this Phase 1b/2 trial in AML are to evaluate the safety of PCM-075 in combination with either low-dose cytarabine or decitabine, and to identify the maximum tolerated dose in Phase 1b to further evaluate the safety and preliminary efficacy in Phase 2.
The median age of patients was 78 years and they were randomised two-to-one to receive eryaspase in combination with low-dose cytarabine (LDAC) versus LDAC alone.
Designed with Jazz's CombiPlex technology, Vyxeos is a unique liposomal formulation that delivers a fixed-ratio of daunorubicin and cytarabine to the bone marrow that has been shown to have synergistic effects at killing leukemia cells in vitro and in animal models.
Cytarabine kullanimi sirasinda bradikardi, perikardit, aritmi veya konjestif kalp yetmezligi gelistiginde ilac ile iliskili olabilecegi mutlaka akla getirilmelidir (3).
According to Mehar news agency, Bortezomib, Cytarabine, Capecitabine, Erlotinib, Vorinostat, and Irinotecan are some of the drugs which were unveiled.
21) In both subtypes, after standard induction therapy with cytarabine and anthracyclines, complete remission can be achieved in approximately 90% of the patient population.
On cycle 2, the patient received intrathecal liposomal cytarabine (Depocyte[R]).
In the case of Cytarabine, used to treat leukemia, doctors have rationed doses.