cystine


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cystine

 [sis´tēn, sis´tin]
a naturally occurring amino acid, the chief sulfur-containing component of the protein molecule. It is sometimes found in the urine and in the kidneys in the form of minute hexagonal crystals, frequently forming cystine calculus in the bladder.
cystine storage disease Fanconi's syndrome (def. 2).

cys·tine

(sis'tēn, sis'tin), Do not confuse this word with cysteine.
3,3'-Dithiobis(2-aminopropionic acid); the disulfide product of two cysteines in which two -SH groups become one -S-S- group; if two cysteinyl residues in polypeptide chains form a disulfide linkage, then the two polymers are cross-linked; sometimes occurs as a deposit in the urine, or forming a vesical calculus. Compare: meso-cystine.
Synonym(s): dicysteine

cystine

/cys·tine/ (sis´tēn) (sis´tin) a sulfur-containing amino acid produced by digestion or acid hydrolysis of proteins, sometimes found in the urine and kidneys, and readily reduced to two molecules of cysteine.

cystine

(sĭs′tēn′)
n.
A white crystalline amino acid, C6H12N2O4S2, that is formed from the disulfide linkage of two cysteines during the folding of many proteins, especially keratin, and stabilizes the tertiary structure of the protein.

cystine

[sis′tin]
a compound consisting of two cysteine residues joined by a disulfide (S-S) linkage. Compare cysteine.
enlarge picture
Chemical structure of cystine

cys·tine

(sis'tēn)
The disulfide product of two cysteines in which two -SH groups become one -S-S- group; sometimes occurs as a deposit in the urine, or forming a vesical calculus.
Cystineclick for a larger image
Fig. 127 Cystine . Formation of cystine.

cystine [Cys-Cys]

an amino acid residue formed by the OXIDATION of the sulphydryl groups [SH] of two CYSTEINES generating a DISULPHIDE BRIDGE (S-S); See Fig. 127 . In some PROTEINS, side chains can be cross-linked by disulphide bridges as a result of the formation of cystines. See SULPHUR BRIDGE.

cystine

a naturally occurring amino acid, an important sulfur-containing component of the protein molecule. It is sometimes found in the urine and in the kidneys in the form of minute hexagonal crystals, frequently forming cystine calculus in the bladder.
Enlarge picture
Cystine stones. By permission from Nelson RW, Couto CG, Small Animal Internal Medicine, Mosby, 2003

cystine calculi
see cystine uroliths.
References in periodicals archive ?
Ocular cystinosis is diagnosed when the pathognomonic refractive cystine crystal accumulations are observed throughout the conjunctiva and entire cornea (central and peripheral) on anterior segment examination.
The general goal of fluid intake is to reduce the concentration of cystine to less than 250 mg/L at pH 7, and patients should be counseled on the importance of maintaining high fluid intake.
For years, the generally accepted therapeutic target for cystine in mixed leukocytes has been <1.
01%) like alanine, aspartic acid, cysteine, cystine, glutamine, histidine, lysine, tyrosine, thiamine, leucine and lysine supplemented in the basal medium was investigated for Ftase production by the fungal isolates.
However, difficulties encountered during visualisation of the stone, presence of impacted and/or calcium oxalate monohydrate and cystine stones, actual health state of the patient lower the success rates of ESWL and lead to preference of URS in such cases.
Crude protein and methionine + cystine levels were valorized by preparing control diet (composition and calculated nutritional levels) without the inclusion of protease in each production phase.
Moringa is also a good source of protein including large amounts of the sulfur-containing amino acids, methionine and cystine.
Nephropathic cystinosis is a rare, inherited condition caused by a build up of cystine that affects every cell in the body.
Then he surveys the chemical modification of various proteins: cysteine, cystine, methionine, carboxyl groups in proteins, tyrosine residues, tryptophan, amino groups, histidine, and arginine.
Mutation causes the defective transport of the amino acid cystine out of the lysosome (2) leading to its intracellular accumulation in various organs.
These stones were submitted for chemical analysis for calcium, uric acid, cystine, oxalate, carbonate, phosphate, ammonia, and magnesium contents using stone analysis kit (Merck).
The only exception being cystine whose value was the same for both the treated (at 1 M and 2M NaOH) and untreated seed cakes.