cysteine sulfinic acid

cys·te·ine sul·fin·ic ac·id

(sis-tē'ēn sul-fin'ik as'id),
A natural oxidation product of cysteine; an intermediate in the formation of taurine (using cysteic acid).
References in periodicals archive ?
Los genes de interes evaluados para este estudio fueron: Aminomethyltransferase, Glycine dehydrogenase, Glycine hydroxymethyltransferase, [DELTA]-1-pyrroline-5-carboxylate synthase, Ornithine aminotransferase, Arginase, Alanine transaminase, Alanine-glyoxylate transaminase, Glutamate decarboxylase, Glutamate decarboxylase 1-2, Spermidine synthase, Aldehyde dehydrogenase, ATP-grasp domain-containing protein, Cysteine sulfinic acid decarboxylase1-2, Taurine transporter, HSP beta 1, Sodium- and chloride-dependent glycine transporter (Meng et al., 2013; Cross et al., 2014; Eierman & Hare, 2014).
Lowther, "Reduction of cysteine sulfinic acid in peroxiredoxin by sulfiredoxin proceeds directly through a sulfinic phosphoryl ester intermediate," The Journal of Biological Chemistry, vol.
Furdui, "Identification of intact protein thiosulfinate intermediate in the reduction of cysteine sulfinic acid in peroxiredoxin by human sulfiredoxin," The Journal of Biological Chemistry, vol.
Chang et al., "Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-Cys peroxiredoxins," The Journal of Biological Chemistry, vol.
Hwang et al., "Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation," Science, vol.
Cysteine is oxidized by cysteine dioxygenase (CDO; EC 1.13.11, MW 24 kD) to cysteine sulfinic acid which is converted by CSAD to hypotaurine which is then oxidized to taurine.
Cysteine sulfinic acid decarboxylase (CSAD) is one of rate-limiting enzymes for taurine biosynthesis [2,13] and the level of its activity determines the need for dietary taurine.
However, as the activities of cysteine dioxygenase (CD) and cysteine sulfinic acid decarboxylase (CSAD), which are enzymes involved in taurine synthesis, are too low to trigger taurine biosynthesis in the human body (Rigo and Senterre, 1977; Sturman and Hayes, 1980), taurine must be supplied by outside sources.
The major pathway is Cys oxidization into cysteine sulfinic acid, decarbonization into hypotaurine, and finally oxidization into taurine.
Sue, "Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine," Journal of Biological Chemistry, vol.
Hypotonicity causes astrocytes and neurons to incorporate cysteine sulfinic acid and synthesize taurine through the use of cysteine sulfinic acid decarboxylase (CSAD; EC 4.1.1.29) [11, 13].
However, as the activities of cysteine dioxygenase (CD) and cysteine sulfinic acid decarboxylase (CSAD) which are enzymes involving in taurine synthesis are too low to trigger taurine biosynthesis in the human body (Rigo and Senterre, 1977; Sturman and Hayes, 1980), taurine should be supplied from outside.
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