cystatin C


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cystatin C

(sĭs′tăt-ĭn)
A cysteine proteinase inhibitor found in the bloodstream in elevated concentrations in patients with impaired kidney function. It is a small protein composed of 120 amino acids (mass 13 kD) that is produced by nucleated cells throughout the body and easily filtered by the glomeruli of the kidneys. It is reabsorbed and catabolized by proximal tubular cells. Because levels of cystatin C do not depend on a patient's age, height, muscle mass, or weight, it is thought to be a better measure of kidney function than the creatinine clearance test, which is most often used to assess renal health.
References in periodicals archive ?
The leading cause for early termination from FORTITUDE-ALS for patients who received placebo was progressive disease; the leading cause for early termination for patients who received reldesemtiv was a decline in cystatin C based estimated glomerular filtration rate, a measure of renal function.
Cytokinetics announces results of FORTITUDE-ALS
Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med.
Comparison of serum levels of Cystatin-C and traditional renal biomarkers for the early detection of pre-hypertensive nephropathy
Cystatin C is a biomarker recommended for use in GFR calculations because it is easily glomerular-filtered, has a low molecular weight and is not dependent on muscular mass (5,6).
Evaluation of Renal Function in Obese Children and Adolescents Using Serum Cystatin C Levels, Estimated Glomerular Filtration Rate Formulae and Proteinuria: Which is most Useful?
Cystatin C is a small (13 kDa) cysteine proteinase inhibitor, produced by all nucleated cells at a constant rate.
Cystatin C--a biomarker for the early risk assessment of renal impairment
Cystatin C (CysC) is a more sensitive biomarker than serum creatinine or estimated glomerular filtration rate.
Increased Serum Cystatin C in Early Parkinson's Disease with Objective Sleep Disturbances
THURSDAY, May 3, 2018 (HealthDay News) -- Reduced kidney function, estimated using cystatin C, is associated with 20-year cumulative incidence of hearing impairment (HI), according to a study published online April 26 in JAMA Otolaryngology-Head & Neck Surgery.
Cystatin C Tied to Cumulative Hearing Impairment; Cystatin C as biomarker, kidney function marker linked to 20-year cumulative incidence of HI
Although the equations are constructed differently, the calculation of both CKD-EPI and MDRD is based on the 2 renal biomarkers: creatinine and cystatin C (3-5).
Biological Variation of Creatinine, Cystatin C, and eGFR over 24 Hours
In recent years, cystatin C, a 13-kD proteinase inhibitor, has also been suggested as a novel marker of renal function.
First Report on the Percentiles of the Glomerular Filtration Rate in Iranian Children Using the 2009 Schwartz Equations
Cystatin C at hour 6 was lower than the value measured at hour 24 (p = 0.0142).
Evaluation of the effect of Retrograde Intrarenal Surgery with Myo-Inositol Oxygenase
Danielsen, "Serum cystatin C as a marker ofthe renal function," Scandinavian Journal of Clinical & Laboratory Investigation, vol.
Estimating Renal Function in the Elderly Malaysian Patients Attending Medical Outpatient Clinic: A Comparison between Creatinine Based and Cystatin-C Based Equations
Cystatin C may be a superior marker in critical illness because it is not affected by muscle mass [11].
Creatinine--and Cystatin C-Based Incidence of Chronic Kidney Disease and Acute Kidney Disease in AKI Survivors
Objective: To compare e-GFR estimated by creatinine or cystatin C based and combined creatinine and cystatin C based equations in type 2 diabetics in different stages of albuminuria.
COMPARISON OF RENAL FUNCTION ASSESSMENT BY CYSTATIN C AND CREATININE BASED EQUATIONS FOR e-GFR IN TYPE 2 DIABETICS IN DIFFERENT STAGES OF ALBUMINURIA
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