Objective: To compare e-GFR estimated by creatinine or cystatin C
based and combined creatinine and cystatin C
based equations in type 2 diabetics in different stages of albuminuria.
A blood test of kidney function known as cystatin C
has been shown to be an alternative, better marker of creatinine, compared with GFR, and is supported by the Kidney Disease: Improving Global Outcomes CKD work group's 2012 clinical practice guidelines for the evaluation and management of CKD.
Today, there are three primary measured biomarkers used in CKD diagnosis and management: creatinine, urine albumin (UAlb), and cystatin C
The previous studies have suggested that serum cystatin C
concentration is a better indicator of GFR than the serum creatinine concentration in patients with spine injury, liver cirrhosis, diabetes, mild-to-moderate impaired kidney function and in elderly patients.
We would like to comment on the article "Performance in Measurement of Serum Cystatin C
by Laboratories Participating in the College of American Pathologists 2014 CYS Survey" reporting substantial method-specific biases for cystatin C
The major inhibitor of cathepsin S in extracellular fluids including plasma is cystatin C
which is expressed by alveolar macrophages, bronchioepithelial cells, and endothelial cells [10-12].
It is produced by all nucleated cells and freely filtered by the glomerular membrane, entirely catabolized by proximal tubule, without secretion, and serum concentration of cystatin C
is determined by GFR.
One of these markers which seem ideal for assessing the GFR is cystatin C
Aims and Objectives: To evaluate serum cystatin C
and its correlation with biochemical, clinical, and anthropometric parameters in patients with type 2 diabetes and healthy controls.
Cockcroft-Gault, CKD-EPI serum cystatin C
, and CKD-EPI creatinine-serum cystatin C
equations were compared in secondary analyses.
is a 13-kDa cysteine protease inhibitor produced at a constant rate by most nucleated cells.
Keywords: Cystatin C
, Kidney donor, Glomerular Filtration rate.