cystathionine gamma-lyase


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cys·ta·thi·o·nine γ-ly·ase

(sis'tă-thī'ō-nēn lī'ās),
A liver enzyme, requiring pyridoxal phosphate as coenzyme, which catalyzes the hydrolysis of l-cystathionine to l-cysteine and 2-ketobutyrate, releasing NH3; also catalyzes formation of 2-ketobutyrate from l-homoserine, of pyruvate (and NH3 and H2S) from l-cysteine, and of thiocysteine, pyruvate, and NH3 from cystine. A deficiency of this enzyme results in cystathioninuria. It catalyzes a step in methionine catabolism and in cysteine biosynthesis.
See also: cystathionine β-lyase.
References in periodicals archive ?
The presentation describes the engineering of the cystathionine gamma-lyase enzyme scaffold into a novel molecule with a unique specificity for degrading both cystine and cysteine.
Sequence of cDNA for rat cystathionine gamma-lyase and comparison of deduced amino acid sequence with related escherichia coli enzymes.
The key stemness genes glutaminase 2 (GLS2), cystathionine-beta-synthase (CBS), and cystathionine gamma-lyase (CTH) were enriched in CTC-MCC-41, whereas CD200 molecule (CD200), spalt like transcription factor 4 (SALL4), and inhibitor of DNA binding 1 (ID1) were over-represented in HT-29.
You et al., "Dysregulation of cystathionine gamma-lyase (CSE)/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophage," Cellular Signalling, vol.