was generated by transmethylation in the process of Met metabolism , and then cystathionine
transsulfuration produced cysteine , and cysteine finally transformed into taurine , which plays important roles in antioxidant .
His homocysteine improved but his mismatch with cystathionine
worsened so we added in the activated form of vitamin B6 in the pyridoxyl 5-phosphate (P-5-P) form.
If methionine is in excess than homocysteine is irreversibly converted to cysteine by cystathionine
beta synthase with vitamin B6 as cofactor.
In addition to the above-mentioned S-sulfhydrated proteins, S-sulfhydration of cystathionine
[beta]-synthase (CBS) and cystathionine
[gamma]-lyase (CSE), [H.
beta-synthase or thermolabile methylenetetrahydrofolate reductase enzymes, and vitamins like B12, B6 and folic acid are the cofactors in the metabolism of Hcy.
Key enzymes involved in the one-carbon methylation of As with S-adenosyl methionine (SAM) as the methyl donor include arsenic-3-methyltransferase (AS3MT), methylenetetrahydrofolate reductase (MTHFR), cystathionine
beta-synthase (CBS), and PNP.
2]S facilitates the induction of hippocampal long-term potentiation (LTP) by enhancing the activity of N-methyl D-aspartate (NMDA) receptors, and that cystathionine
[beta]-synthase (CBS) produces [H.
The natural history of homocystinuria due to cystathionine
Well-rounded support for methylation (MET) as well as cystathionine
beta synthase (CBS) pathways appeared well tolerated in this study.
Third, the transsulfuration pathway from homocysteine to cystathionine
which is catalyzed by cystathionine
beta synthase (CBS) is tightly related to the methylation pathway.
Is the increase in serum cystathionine
levels in patients with liver cirrhosis a consequence of impaired homocysteine transsulfuration at the level of gamma-cystathionase?
- This enzyme acts in a chemical pathway and is P-synthase responsible for using vitamin B6 to convert building block of proteins (amino acid) called homocysteine and serine to a molecule called cystathionine