beta-synthase or thermolabile methylenetetrahydrofolate reductase enzymes, and vitamins like B12, B6 and folic acid are the cofactors in the metabolism of Hcy.
Key enzymes involved in the one-carbon methylation of As with S-adenosyl methionine (SAM) as the methyl donor include arsenic-3-methyltransferase (AS3MT), methylenetetrahydrofolate reductase (MTHFR), cystathionine
beta-synthase (CBS), and PNP.
2009) who found that there was a decrease in PLP-dependent enzymes (cystathionine
Psynthase and cystathionine
[gamma]-lyase) in the transsulfuration pathway for degradation of homocyteine when this vitamin was deficient.
Well-rounded support for methylation (MET) as well as cystathionine
beta synthase (CBS) pathways appeared well tolerated in this study.
Vitamin B12 is an essential cofactor in homocysteinemeta bolisem to methionine and vitamin B6 by cystathionine
6 synthase converts homocysteine to cystathionine
- This enzyme acts in a chemical pathway and is P-synthase responsible for using vitamin B6 to convert building block of proteins (amino acid) called homocysteine and serine to a molecule called cystathionine
beta-synthase mutations in homocystinuria.
6] insufficiency result in increased homocysteine concentrations because they are cofactors for methionine synthase and cystathionine
Familial thrombophilia associated with homozygosity for the cystathionine
[beta]-synthase 833T-C mutation.
Several articles pointed out that this change in the arteries and the tendency to develop blood clots and thrombi could be due either to the homocysteine or to the elevated methionine, which is a closely related amino acid; or it could be due to a deficiency of cystathionine
, the next chemical in the degradation pathway of homocysteine.
The patent now will cover only homocysteine assays that use any of the following three enzymes: cystathionine
[eth]-synthetase, betaine-homocysteine-methyltransferase, and methyl-tetrahydrofolic acid methyltransferase (methionine synthase).
Abbreviations: Ado, adenosine; BHMT, betaine-homocysteine S-methyltransferase; CBS, cystathionine
[beta]-synthase; DHF, dihydrofolate; DMG, dimethylglycine; Glu, glutamate; Gly, glycine; GSH, glutathione; MS, methionine synthase; MT, methyltransferase; MTHFR, methylenetetrahydrofolate reductase; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine; THF, tetrahydrofolate; Zn, zinc.