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Decarboxycystine; forms when cystine is distilled. The disulfide of cysteamine.
References in periodicals archive ?
In conjunction with other fibrotic conditions, Raptor's acquired license covers the use of cysteamine or cystamine in the potential amelioration of progressive interstitial renal fibrosis by modulating oxidative stress.
Direct methods of preventing polyQ protein aggregation using molecules such as Congo Red and cystamine, which act to stabilise the native non-toxic conformation of the protein, prevent cross-linking of the mutant isoform, or promote clearance from the cell, have also been attempted.
In treatment groups cystamine was supplemented at three levels (0, 100, 500 [micro]M).
Thiol-containing amino acids were analyzed with cystamine as an internal standard as previously described (21).
This European Patent 1919458 reportedly covers the use of any composition of cysteamine or cystamine, regardless of the specific formulation, that provides increased delivery to the small intestine with pharmacokinetic benefits that allow for twice daily dosing in the treatment of nephropathic cystinosis.
Protein A, cystamine dihydrochloride, and concanavalin A (ConA) were purchased from Sigma.
tHcy and tCys in EDTA plasma were analyzed simultaneously by HPLC after the reduction of plasma disulfides with tris(2-carboxyethyl)phosphine, precipitation of proteins with trichloroacetic acid, derivatization with 7-fluoro-2,1,3-benzoxadiazole-4-sulfonate (SBD-F), and fluorescent detection as described previously (10) using cystamine as an internal standard.