45) Drugs such as cyclothiazide (46) or 4-chlorom-cresol, (47) or some lipid mediators48) inhibit voltagegated [K.
2001) Mechanisms underlying presynaptic facilitatory effect of cyclothiazide at the calyx of Held of juvenile rats.
Kainic acid, 2-amino-3-(5-methy1-3-oxo-1,2-oxazol-4-y1), propanoic acid (AMPA), and cyclothiazide (CTZ) were purchased from Tocris Biosciences (UK).
Squid GluRs displayed a strong desensitization to glutamate that was removed by cyclothiazide (CTZ), which is a compound that stabilizes the non-desensitized state of AMPA receptors in vertebrates (Partin et al.
85 PARTIN KM,NEURON,vol 0011,page 1069,1993,cites= 37,SELECTIVE MODULATION OF DESENSITIZATION AT AMPA VERSUS KAINATE RECEPTORS BY CYCLOTHIAZIDE
When the high-frequency stimulation was delivered in the presence of cyclothiazide
, a drug that reduces glutamate receptor desensitization, the depression of the second and third EPSPs was reduced.