cyclosporin


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cycloSPORIN1

[-spôr′ēn]
an alternative term for cyclosporin A, an immunosuppressive medication often administered after organ transplants.

cyclosporin2

[-spôr′in]
any of a group of biologically active metabolites of Tolypocladium inflatum Gams and certain other fungi. Nine have been identified and are designated cyclosporin A through I. The major forms are cyclosporin A and C, which are cyclic oligopeptides with immunosuppressive, antifungal, and antipyretic effects. As immunosuppressants, cycloSPORINE primarily affect T lymphocytes. They are widely used in organ transplantation to suppress rejection and are known to be a human carcinogen. Also spelled ciclosporin.

cyclosporin

Ciclosporin, an important immunosuppressant drug that has greatly reduced the rate of rejection of grafted organs such as kidneys and hearts. It acts by interfering with the multiplication of immunocompetent T lymphocytes. Brand names are Neoral and Sandimunn.
References in periodicals archive ?
7% LFTA in 66 recipients of cadaveric kidneys treated with cyclosporin A and prednisone.
Cyclosporin increases local glomerular synthesis of reactive oxygen species in rats; effects of vit E on cyclosporine induced nephrotoxicity.
Cyclosporin A: a new drug in veterinary dermatology.
S100A8 and S100A9 calcium-binding proteins: localization within normal and cyclosporin A-induced overgrowth gingiva.
Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus.
Rapid liquid chromatography-tandem mass spectrometry routine method for simultaneous determination of sirolimus, everolimus, tacrolimus, and cyclosporin A in whole blood.
Prevalence, severity, and risk variables associated with gingival overgrowth in renal transplant subjects treated under tacrolimus or cyclosporin regimens.
Syngeneic peripheral blood stem cell transplantation using immunosuppressive treatment with antithymocyte globulin and cyclosporin A without high-dose pre-transplant conditioning was performed, followed by complete hematologic and hepatic recovery.
They have also found this cyclophilin to be the target of DEBIO-025, a derivative of the immunosuppressant cyclosporin, which is used primarily in the context of organ transplantation.
The immune-suppressing drug Cyclosporin is made from the fungal species Beauveria Nivea.
The cyclophilins constitute a large family of well-conserved genes, some of which are also known as immunophilins due to the fact that these proteins are the targets of the potent immunosuppressive drug cyclosporin A (CsA) (Liu et al.
The large body of data regarding the use of cyclosporin A during pregnancy comes from the transplant literature.