cyclosporin


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cyclosporin

Ciclosporin, an important immunosuppressant drug that has greatly reduced the rate of rejection of grafted organs such as kidneys and hearts. It acts by interfering with the multiplication of immunocompetent T lymphocytes. Brand names are Neoral and Sandimunn.
References in periodicals archive ?
Uchino et al., "Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat," Brain Research, vol.
Hyponatraemia and hyperkalaemia are more frequent in renal transplant recipients treated with tacrolimus than with cyclosporin. Further evidence for differences between cyclosporin and tacrolimus nephrotoxicities.
Thalidomide shows immunomodulatory activity through suppression of tumour necrosis factor-alpha, basic fibroblast growth factor and neutrophil chemotaxis.10 A study was carried out by Elgart, that included four patients with pyoderma gangrenosum unresponsive to treatment with prednisone, cyclosporin, colchicine, cytoxan, and dapsone.
All patients received initial immunosuppres-sive therapy with prednisolone (P), antimetabolites (mycophenolatemofetil-(MMF), azathioprine-(AZA)) combined with calcineurin inhibitors (CNI; cyclosporin A-CyA/, tacrolimus-Tac), interleukin-2 receptor antagonists (IL-2ra) or mechanistic target of rapamycin (mTOR) inhibitors (sirolimus(SRL)/ everolimus (EVL)).
Surgeons already use existing drugs such cyclosporin to achieve the same outcome after a transplant, to stop the body rejecting a donated organ.
Cyclosporine or cyclosporin A (CsA), initially isolated from fungus Tolypocladium inflatum, is a powerful immunosuppressant drug widely used in organ transplantation to prevent rejection in human medicine (Guaguere, 2004).
* Cyclosporin, methotrexate, oral corticosteroids, azathioprine,
Cyclosporin A (CYSP), a hydrophobic cyclic peptide, is widely used as an immunosuppressant drug for transplant therapy [1, 2].
Effect of cyclosporin A on apoptosis and expression of p53 and bcl-2 proteins in the gingiva of renal transplant patients.
Double-masked trial of cyclosporin versus colchicines and long-term open study of cyclosporin in Behcet\'s disease.