Uchino et al., "Amelioration by cyclosporin
A of brain damage in transient forebrain ischemia in the rat," Brain Research, vol.
Hyponatraemia and hyperkalaemia are more frequent in renal transplant recipients treated with tacrolimus than with cyclosporin
. Further evidence for differences between cyclosporin
and tacrolimus nephrotoxicities.
Thalidomide shows immunomodulatory activity through suppression of tumour necrosis factor-alpha, basic fibroblast growth factor and neutrophil chemotaxis.10 A study was carried out by Elgart, that included four patients with pyoderma gangrenosum unresponsive to treatment with prednisone, cyclosporin
, colchicine, cytoxan, and dapsone.
All patients received initial immunosuppres-sive therapy with prednisolone (P), antimetabolites (mycophenolatemofetil-(MMF), azathioprine-(AZA)) combined with calcineurin inhibitors (CNI; cyclosporin
A-CyA/, tacrolimus-Tac), interleukin-2 receptor antagonists (IL-2ra) or mechanistic target of rapamycin (mTOR) inhibitors (sirolimus(SRL)/ everolimus (EVL)).
induced effects on foetal kidney in albino mice.
Surgeons already use existing drugs such cyclosporin
to achieve the same outcome after a transplant, to stop the body rejecting a donated organ.
Cyclosporine or cyclosporin
A (CsA), initially isolated from fungus Tolypocladium inflatum, is a powerful immunosuppressant drug widely used in organ transplantation to prevent rejection in human medicine (Guaguere, 2004).
, methotrexate, oral corticosteroids, azathioprine,
A (CYSP), a hydrophobic cyclic peptide, is widely used as an immunosuppressant drug for transplant therapy [1, 2].
Effect of cyclosporin
A on apoptosis and expression of p53 and bcl-2 proteins in the gingiva of renal transplant patients.
A for psoriasis," New England Journal of Medicine, vol.
Double-masked trial of cyclosporin
versus colchicines and long-term open study of cyclosporin
in Behcet\'s disease.