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Intracellular proteins associated with heat shock proteins and other molecules (e.g., glucocorticoid receptors). Cyclophilins mediate immunosuppressive actions of antirejection drugs (e.g., cyclosporine and FK-506).
[cyclo- + G. philia, love, attraction, + -in]
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Crameri, "Cyclophilins, a new family of cross-reactive allergens," European Journal of Immunology, vol.
In present investigation the Cyclophilin A (CypA) of white leg shrimp (Litopenaeus vannamei) has been cloned by rapid amplification of cDNA (RACE) and anchored PCR method.
Depletion of cyclophilins B and C leads to dysregulation of endoplasmic reticulum redox homeostasis.
For example, PmCYP from Prorocentrum minimum showed a similar cyclophilins family conserved sequence and had five signature motifs; however, instead of a signal peptide, PmCYP had a cytoplasmic signal sequence predicting its cytoplasmic location [29].
CPI-431-32 is a next-generation non-immunosuppressive cyclophilin inhibitor shown to have best-in-class potency against hepatitis B virus and a significantly larger selective index compared to previously known cyclophilin inhibitors.
S.Characterization of the cyclophilin gene family of Arabidopsis thaliana and phylogenetic analysis of known cyclophilin proteins.
Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein.
In addition, similar to other cyclophilins, CyPA possesses an activity of peptidyl-prolyl cis-trans isomerase which catalyzes the isomerization of peptide bonds from trans form to cis one at proline residues to prompt protein folding [4, 22] and may play crucial roles in many biological conditions including protein folding, trafficking, assembly, T cell activation, and cell signaling [4, 23].
Pfefferle S, Schopf J, Kogl M, Friedel CC, Muller MA, Carbajo-Lozoya J, Stellberger T, von Dall'Armi E, Herzog P, Rallies S, Niemeyer D, Ditt V, Kuri T, Zust R, Pumpor K, Hilgenfeld R, Schwarz F, Zimmer R, Steffen I, Weber F, Thiel V, Herrler G, Thiel HJ, Schwegmann-Wessels C, Pohlmann S, Haas J, Drosten C, von Brunn A (2011) The SARS-coronavirus-host interactome: Identification of cyclophilins as target for pan- coronavirus inhibitors.
Cyclophilins are ubiquitous proteins in human cells that are involved in protein folding.
The researchers say that they analysed liver cells to determine which variant of cyclophilins is critical for hepatitis C virus replication, and found that blocking cyclophilin A leads complete inhibition of virus replication.