PPIB

(redirected from cyclophilin B)

PPIB

A gene on chromosome 15q21-q22 that encodes peptidylprolyl cis-trans isomerase B (cyclophilin B), which, as with other PPIs, accelerates protein folding. It catalyses the cis-trans isomerisation of proline-imidic peptide bonds in oligopeptides.

Molecular pathology
Defects in PPIB cause osteogenesis imperfecta type 9.
References in periodicals archive ?
Jia, "N-methyl-4-isoleucine cyclosporine attenuates CCl4-induced liver fibrosis in rats by interacting with cyclophilin B and D," Journal of Gastroenterology and Hepatology, vol.
Cyclophilin B mediates cyclosporin A incorporation in human blood T-lymphocytes through the specific binding of complexed drug to the cell surface.
These results confirm that the CpCYP identified in the present study (see Figure 2) belongs to cyclophilin B group, while our previous CYP identified from P minimum should belong to CYP A [29].