cyclophilin


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cyclophilin

Any of a family of high-affinity cyclosporin A-binding proteins (cyclophilin A [MIM:123840]; cyclophilin B [MIM:123841]; cyclophilin C [MIM:123842]) that catalyse cis-trans isomerisations. Cyclophilin is the trivial name for peptidylprolyl isomerase, EC 5.2.1.8 (peptidylproline cis-trans-isomerase).
References in periodicals archive ?
ETF-a, apolipoprotein A-I, actin, transgelin, cofilin-1, cyclophilin A, myosin, and galectin-1, were identified in both groups using MALDI-TOF-MS, and they are listed in [Table 4].
The isomerase active site of cyclophilin a is critical for hepatitis C virus replication.
The crystal structure reveals that one hydroxyl side group in cyclosporin actually forms a hydrogen bond with its aminoacid backbone and not with cyclophilin.
Target Gene Sense Cyclophilin A 5'-AGCATACAGGTCCTGGCATC-3' [alpha]-actin 5'-GGCAAGATGAGAGTGCACAA-3' BNP 5'-AAGCTGCTGGAGCTGATAAGA-3' C3 5'-GACTGGGATGTCACCCTGAG-3' CFB 5'-CTTCCTCTTCTGCTGTTCTCC-3' CFH 5'-GCCAAGTGTTCGGTATCCAG-3' NF-kB 5'-ATGGCAGACGATGATCCCTAC-3' IL-6 5'-TAGCCGCCCCACACAGACAG-3' TNF-[alpha] 5'-GCCTCTTCTCATTCCTGCTTG-3' Target Gene Anti-sense Cyclophilin A 5'-AGCTGTCCACAGTCGGAAAT-3' [alpha]-actin 5'-CGGAGAATGATGGTCCAGAT-3' BNP 5'-GTTACAGCCCAAACGACTGA-3' C3 5'-TCACTATGGGACCAGCTTCA-3' CFB 5'-AGCCTTCCTGCCAAGATTCC-3' CFH 5'-GGAGTCAGTTGGTCCCAGAA-3' NF-kB 5'-CGGAATCGAAATCCCCTCTGTT-3' IL-6 5'-GGCTGGCATTTGTGGTTGGG-3' TNF-[alpha] 5'-CTGATGAGAGGGAGGCCATT-3' Table 2.
Abbreviations: APRIL, a proliferation-inducing ligand; BAFF, B-cell-activating factor; BAFFR, B-cell-activating factor receptor; BCMA, B-cell maturation antigen; Ig, immunoglobulin; TACI, transmembrane activator and calcium modulator and cyclophilin ligand.
This study shows that the company's cyclophilin inhibitors can be further developed towards the goal of offering mitochondrial myopathy patients a novel treatment option.
Simon Kerr, chief executive officer, Cypralis, said, "Cyprolides are a new class of fully synthetic cyclophilin inhibitors that are potent inhibitors of cyclophilin D and protect against opening of the mitochondrial permeability transition pore.
tuberculatum venom can be grouped basically into proteins involved in insect metabolism (annexin B9, nucleoside diphosphate kinase; aconitate hydratase; superoxide dismutase; triose phosphate isomerase; glyceraldehyde-3phosphate dehydrogenase; succinyl-CoA ligase; fructosebisphosphate aldolase; arginine kinase; citrate synthase; enolase; ATP synthase; 4-hydroxybutyrate coenzyme A transferase; medium-chain specific acyl-CoA dehydrogenase, and isocitrate dehydrogenase); transport protein (transferrin); and structural proteins (cyclophilin, actin, and chitinase).
The cycle threshold (Ct) values were normalized against the endogenous cyclophilin control and analyzed by using the [DELTA][DELTA]Ct method [17].
Quantitative RT-PCR was carried out according to previous reports [16,33], with iQ SYBR Green mix (Roche, Basel, Switzerland) on an ABI 7500 system; cyclophilin was used for normalization [16, 34].