in cancer: progress and perspective.
This might be due to non-selective inhibition of cyclooxygenases
that provides support in the synthesis of prostanoids necessary for generating signals by APCs (Antigen presenting cells) and transmitting these signals to T cells.
, microsomal prostaglandin E synthase-1, and cardiovascular function.
are known for their role in synthesis of prostaglandins which have gastro protective activity.
Table 2: Expression of renal cyclooxygenases
(COX-1 and -2) in rats with PUUO at 9 and 15 weeks (mean ± SEM) [Table omitted]
Comparative pathophysiology and toxicology of cyclooxygenases
They also discuss in vivo disease models used to study the role of cyclooxygenases
in gastrointestinal injury, inflammation, and pain.
The inhibition of various enzymes of the arachidonic acid cascade, among these the lipoxygenases and the cyclooxygenases
, might be a possible target.
Lipsky LP, Abramson SB, Crofford L, Dubois RN, Simon LS, Van de Putte LB (1998) The classification of cyclooxygenases
Among the physiological activators of platelet, thromboxane A [sub]2 (TXA [sub]2 ) is the primary one which is conversed from arachidonic acid in the platelets and catalyzed by cyclooxygenase
The expression of cyclooxygenase
in transitional cell carcinoma cell lines: its correlation with tumor differentiation, invasiveness and prostanoids production.
(COX), the rate-limiting enzyme in the conversion of arachidonic acid to prostanoids (Sheng et al.