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an activity of the enzyme prostaglandin endoperoxide synthase.

pros·ta·glan·din en·do·per·ox·ide syn·thase

a protein complex that catalyzes two steps in prostaglandin biosynthesis; the cyclooxygenase activity (which is inhibited by aspirin and indomethacin) converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2.
Synonym(s): cyclooxygenase


(sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
1. See COX-1.
2. See COX-2.


An enzyme, found in most tissues, that helps turn some fatty acids into protaglandins.
Mentioned in: Cox-2 Inhibitors
References in periodicals archive ?
Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening.
Tohnai, "Cyclooxygenase isozymes and their gene structures and expression," Prostaglandins & Other Lipid Mediators, vol.
Hla, "Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition," Pharmacological Reviews, vol.
Cyclooxygenases and prostaglandins: shaping up the immune response.
Morteau, Prostaglandins and inflammation: the cyclooxygenase controversy, Archivum Immunologiae et Therapiae Experimentalis, 48(6), 473-480 (2000).
A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke.
Tripathi, "Screening and identification of salicin compound from Desmodium gangeticum and its in vivo anticancer activity and docking studies with cyclooxygenase (COX) proteins from mus musculus," Journal of Proteomics & Bioinformatics, vol.
Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight.
Nonsteroidal antiinflammatory drugs inhibit the activity of cyclooxygenase, the enzyme that catalyzes the synthesis of cyclic endoperoxides from arachidonic acid to form pro-inflammatory and other forms of prostaglandins.
Some were taking a high dose of lumiracoxib, a type of drug known as a cyclooxygenase (COX-2) inhibitor.
Objective.--The expression of CD44, cyclooxygenase 2, and platelet-derived growth factor receptor [alpha] (PDGFR-[alpha]) was evaluated as a potential prognostic factor for survival in patients with RCC.