cyclooxygenase


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cyclooxygenase

 [si″klo-ok´sĭ-jĕ-nās]
an activity of the enzyme prostaglandin endoperoxide synthase.

pros·ta·glan·din en·do·per·ox·ide syn·thase

a protein complex that catalyzes two steps in prostaglandin biosynthesis; the cyclooxygenase activity (which is inhibited by aspirin and indomethacin) converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2.
Synonym(s): cyclooxygenase

cyclooxygenase

/cy·clo·oxy·gen·ase/ (-ok´sĭ-jen-ās) a component of prostaglandin synthase (q.v.).

cyclooxygenase

(sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
n.
1. See COX-1.
2. See COX-2.

cyclooxygenase

[si′klō·ok′səjĕnās]
an activity of the enzyme prostaglandin endoperoxide synthase.

Cyclooxygenase

An enzyme, found in most tissues, that helps turn some fatty acids into protaglandins.
Mentioned in: Cox-2 Inhibitors
References in periodicals archive ?
Cyclooxygenases and prostaglandins: shaping up the immune response.
Morteau, Prostaglandins and inflammation: the cyclooxygenase controversy, Archivum Immunologiae et Therapiae Experimentalis, 48(6), 473-480 (2000).
A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke.
111) This suggests the question, "Is it possible that some of the increased relative risk for acute MI, stroke, and sudden cardiac death is modulated not by effects on cyclooxygenase, but by the underlying clinical condition?
However, CD44 and cyclooxygenase 2 do not seem to be independent prognostic indicators in predicting outcomes for patients with RCC.
Cyclooxygenase isoenzymes: physiological and pharmacological role.
of London, UK) compile 18 chapters that present in vivo and in vitro techniques used in cyclooxygenase research.
The team then tested whether oleocanthal could chemically inhibit two inflammation-inducing enzymes, cyclooxygenase (COX) 1 and COX 2.
Though NSAIDs inhibit an enzyme called cyclooxygenase (COX) and reduce inflammation, many practitioners argue that inflammation is not just a sign of injury; but a necessary component of the healing process.
demonstrated two isoforms of cyclooxygenase, COX-1 and COX-2.
The second study, "Gastrointestinal (GI) Events, Medication Use and Healthcare Costs for New Users of Cyclooxygenase (COX)-2 Inhibitors and Nonselection Drugs (NSAIDs)", found arthritis patients using COX-2s or nonselective NSAIDs only differed in pharmacy costs and had similar upper GI events rates, GI medication use, and total healthcare costs during the year following initial medication use.