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an activity of the enzyme prostaglandin endoperoxide synthase.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pros·ta·glan·din en·do·per·ox·ide syn·thase

a protein complex that catalyzes two steps in prostaglandin biosynthesis; the cyclooxygenase activity (which is inhibited by aspirin and indomethacin) converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2.
Synonym(s): cyclooxygenase
Farlex Partner Medical Dictionary © Farlex 2012


(sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
1. See COX-1.
2. See COX-2.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


An enzyme, found in most tissues, that helps turn some fatty acids into protaglandins.
Mentioned in: Cox-2 Inhibitors
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Tohnai, "Cyclooxygenase isozymes and their gene structures and expression," Prostaglandins & Other Lipid Mediators, vol.
Hla, "Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition," Pharmacological Reviews, vol.
Cyclooxygenases and prostaglandins: shaping up the immune response.
Morteau, Prostaglandins and inflammation: the cyclooxygenase controversy, Archivum Immunologiae et Therapiae Experimentalis, 48(6), 473-480 (2000).
Tripathi, "Screening and identification of salicin compound from Desmodium gangeticum and its in vivo anticancer activity and docking studies with cyclooxygenase (COX) proteins from mus musculus," Journal of Proteomics & Bioinformatics, vol.
Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight.
Nonsteroidal antiinflammatory drugs inhibit the activity of cyclooxygenase, the enzyme that catalyzes the synthesis of cyclic endoperoxides from arachidonic acid to form pro-inflammatory and other forms of prostaglandins.
Some were taking a high dose of lumiracoxib, a type of drug known as a cyclooxygenase (COX-2) inhibitor.
Objective.--The expression of CD44, cyclooxygenase 2, and platelet-derived growth factor receptor [alpha] (PDGFR-[alpha]) was evaluated as a potential prognostic factor for survival in patients with RCC.