46 g) showed the highest cyclooxygenase
inhibitory activity and was further fractionated by MPLC on silica gel using hexane-acetone (10:1, 110 ml; 6:1, 350 ml; 3:1, 600 ml; 1:1, 400 ml) followed by 100% acetone (140 ml) and MeOH (100 ml).
Inhibition of 5-lipoxygenase and cyclooxygenase
enzymes isolated from ram seminal vesicles by alkamides present in E.
inhibitory and antioxidant bioassay-directed extraction and purification of celery seeds yielded sedanolide (1), senkyunolide-N (2), senkyunolide-J (3), 3-hydroxymethyl-6-methoxy-2,3-dihydro-1H-indol-2-ol (4), L-tryptophan (6), and 7-[3-(3,4-dihydroxy-4-hydroxymethyl-tetrahydro-furan-2-yloxy)-4,5-dih ydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy]-5-hydroxy-2-(4-hydro xy-3-methoxy-phenyl)-chromen-4-one (7).
Inhibition of heat-shock protein 70 induction in intestinal cells overexpressing cyclooxygenase
2B), a selective inhibitor of cyclooxygenase
at a concentration that completely inhibited the production of cylcooxygenase-derived factors (Cole et al.
Signaling pathways regulating aromatase and cyclooxygenases
in normal and malignant breast cells.
Giuliano F, Warner TD (1998) Ex-vivo assay to determine the cyclooxygenase
selectivity of non-steroidal anti-inflammatory drugs.
While many of her classmates were waiting tables at restaurants during the summer of 2004, Alicia Smith was in an NIEHS lab investigating how exposure to sodium arsenite regulates the procarcinogenic and proinflammatory enzyme cyclooxygenase
Neither a muscarinic receptor antagonist nor a cyclooxygenase
inhibitor altered the Ch1LW-induced relaxation.
A paper to be presented at the World Congress of Inflammation Societies in Vienna in October will report on BF-389's potent effect on the newly discovered cyclooxygenase
Overexpression of cyclooxygenase
(COX)-2 has been implicated in many pathologic conditions, including cancer.
(COX) is involvecl in the synthesis of prostaglandins.