cycloheximide


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cycloheximide

(sī″klō-hĕks′ă-mīd)
A cytotoxic protein that inhibits the synthesis of proteins by cells.

cycloheximide

an antibiotic produced by Streptomyces griseus that inhibits protein synthesis. It is too toxic and nonselective for common clinical use, but is used in treatment of cancers and management of graft-versus-host reactions following transplantation. Also used agriculturally for the control of fungal diseases of plants and turf and as a bacterial inhibitor in selective media for culturing fungi.
References in periodicals archive ?
De Meyer, "Selective clearance of macrophages in atherosclerotic plaques by the protein synthesis inhibitor cycloheximide," Journal of Pharmacology and Experimental Therapeutics, vol.
Comparative results of paraffin baiting technique and conventional techniques of direct culture on Sabouraud dextrose agar (SDA), Sabouraud dextrose agar with cycloheximide and paraffin agar (PA) in the isolation of Nocardia spp.
Cycloheximide has been shown to delay the decrease in protein levels and inturn increase the time to visible senescence suggesting that protein degradation may lead to senescence symptoms (Courtney et al.
The media were supplemented with cycloheximide (100[micro]g/ml and benomyl (50[micro]g/ml) to prevent fungal growth (Kinkle et al, 1995) The crude oil used was sterilized by filtering through Millipore filter (0.
Aliquots were spread plated in triplicate on 1/10 strength TSA (tryptic soy agar) medium amended with cycloheximide 0.
The material was sown in agar Sabouraud dextrose plus chloramphenicol and cycloheximide (1) and incubated at 37[degrees]C for up to ten days.
Nuclear dynamics of parthenogenesis of bovine oocytes matured in vitro for 20 and 40 hours and activated with combined ethanol and cycloheximide treatment.
1973, "Effect of lactose, ethanol and cycloheximide on the translocation pattern of radioactive compounds and sclerotium formation in Sclerotium rolfsii," J.
Metallothionein synthesis probably occurs through formation of a specific mRNA because both cycloheximide and actinomycin D, administered concomitantly with cadmium, block the incorporation of [[sup.
Therefore, most bacteria grown on FMA should have been able to digest keratin and were therefore, considered keratin degrading, Both media contained 100 [mu]g/ml of cycloheximide to inhibit fungal growth (Smit et al.
3], 15 g de bactoagar, 5 g de KBr, 100 mg de cycloheximide, 2 mg de benomyl, 25 mg de cefalexina, 30 mg de novobiocin, 50 mg de kasugamicina y 1 L de agua destilada), selectivos para X.