TNX-102 SL (cyclobenzaprine
HCl sublingual tablets) is an investigational new drug and has not been approved for any indication.
has not been studied in patients with CPP.
On the morning of Day 2 predose, which assesses the next day residual effects ("hangover"), tolperisone was no different than placebo (p=0.7) for SDLP, while cyclobenzaprine
demonstrated significant impairment (p=
In addition, the transmucosal absorption of cyclobenzaprine
increases the rate of absorption into the blood stream and bypasses first pass liver metabolism, said the company.
Hoyte, "Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine
, and levetiracetam: case report," Clinical Toxicology, vol.
After 12 weeks of nightly use at bedtime, 5.6 mg of sublingual cyclobenzaprine
(CBP) resulted in a significant reduction on the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5), compared with placebo.
The name of the generic drug cyclobenzaprine
has been truncated to "cycloprine" in certain brand names (e.g., Riva-Cycloprine).
Comparison of amitriptyline, cyclobenzaprine
, and placebo in the treatment of fibromyalgia.
Working with a panel of experts, MetaStar chose four potentially inappropriate medications: amitriptyline, cyclobenzaprine
, glyburide, and propoxyphene.
The company's proprietary products in the United States include: AMRIX (cyclobenzaprine
hydrochloride extended-release capsules), TREANDA (bendamustine hydrochloride) for Injection, FENTORA (fentanyl buccal tablet) (C-II), PROVIGIL (modafinil) Tablets (C-IV), TRISENOX (arsenic trioxide) injection, GABITRIL (tiagabine hydrochloride), NUVIGIL (armodafinil) Tablets (C-IV) and ACTIQ (oral transmucosal fentanyl citrate) (C-II).
The company's proprietary products in the United States include: PROVIGIL(r) (modafinil) Tablets [C-IV], FENTORA(r) (fentanyl buccal tablet) [C-II], TRISENOX injection, TREANDA, AMRIX(r) (cyclobenzaprine
hydrochloride extended-release capsules), VIVITROL(r) (naltrexone for extended-release injectable suspension), GABITRIL(r) (tiagabine hydrochloride), NUVIGIL(tm) (armodafinil) Tablets [C-IV] and ACTIQ(r) (oral transmucosal fentanyl citrate) [C-II].
A muscle relaxant called cyclobenzaprine
(Flexeril) may temporarily help to improve sleep and reduce pain.