Furthermore, it has been shown that inflammatory cytokines, matrix metalloproteinases (MMPs), and cyclo-oxygenases increased in the subacromial bursa of patients with SAIS and rotator cuff disease (6, 7).
It has been shown that inflammatory cytokines (interleukin [IL]-1, IL-6, tumor necrosis factor [TNF-[alpha]]), MMPs, and cyclo-oxygenases increase in the subacromial bursa of patients with SAIS (6, 7, 20).
Proposed mechanisms include inhibition of pro-inflammatory signals such as prostaglandins, leukotrienes and cyclo-oxygenases
. Whilst observational studies have demonstrated statistically significant differences in pain scores in patients with osteoarthritis after curcumin intervention, clinical trials are more appropriate in determining cause and effect.
(3) Inflammatory mediators include the eicosanoids, biologically active lipids formed from arachidonic acid by cyclo-oxygenases
, lipoxygenases or epoxygenases.
It is one of the groups of enzymes in this process, known as cyclo-oxygenases
, that are the main targets for the antipyretic drugs acetaminophen and ibuprofen.
Kinetic basis for selective inhibition of cyclo-oxygenases
. Biochem J 1999 May; 339(Pt 3):607-614.