cyclo-oxygenases

cyclo-oxygenases

A family of enzymes that convert arachidonic acid to prostaglandins which are commonly mediators of pain. Inhibitors of this enzyme include aspirin and many of the large group of NSAID drugs. Also known as prostaglandin synthases.
References in periodicals archive ?
Proposed mechanisms include inhibition of pro-inflammatory signals such as prostaglandins, leukotrienes and cyclo-oxygenases.
The cyclo-oxygenases produce the different prostaglandins that have been extensively studied for their role in human diseases including inflammation, cancer, arthritis and cardiovascular diseases.
It is one of the groups of enzymes in this process, known as cyclo-oxygenases, that are the main targets for the antipyretic drugs acetaminophen and ibuprofen.
Kinetic basis for selective inhibition of cyclo-oxygenases.