This complex is used for the determination of antihistamine (cyclizine hydrochloride) in pure and pharmaceutical formulations.
Keywords: Cyclizine hydrochloride, m-dinitrobenzene, spectrophotomerty.
Cyclizine hydrochloride is a piperazine derivative (Fig.
The idea behind the study was to develop a new spectrophotometric method for the determination of cyclizine hydrochloride in pure and its dosage forms.
Absorption Spectrum of Coloured Complex Cyclizine hydrochloride reacts with m- dinitrobenzene at 100degC in basic media to give purple complex, the absorption spectra of which under optimum conditions lies at 540 nm (Fig.
The results for the determination of cyclizine hydrochloride are shown in Table-1 and 2, which show the sensitivity, validity and repeatability of the method.
Table-1: Determination of cyclizine hydrochloride from pure solution.
cyclizine hydrochloride cyclizine hydrochloride Relative standard