CDKN1B

(redirected from cyclin-dependent kinase inhibitor p27)

CDKN1B

A gene on chromosome 12p13.1-p12 that encodes a cyclin-dependent kinase inhibitor, which binds to and prevents activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, thus controlling cell cycle progression at G1. Degradation of cyclin-dependent kinase inhibitor 1B is triggered by its CDK-dependent phosphorylation and subsequent ubiquitination by SCF complexes, and is a necessary step for cell transition from quiescence to the proliferative state.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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Miskimins, "Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation," Molecular and Cellular Biology, vol.
Expression of cyclin E and the cyclin-dependent kinase inhibitor p27 in malignant lymphomas--prognostic implications.
Increased proteosome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma.
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science.

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