CDK9

(redirected from cyclin-dependent kinase 9)
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CDK9

A gene on chromosome 9q34.1 that encodes a cyclin-dependent kinase, which regulates cell cycle progression. CDK9 is part of the multiprotein complex TAK/P-TEFb, an elongation factor for RNA polymerase II-directed transcription, which acts by phosphorylating the C-terminal domain of a subunit of RNA polymerase II. 

Molecular pathology
HIV-1 Tat protein interacts with CDK9 and cyclin T, suggesting CDK9 may have a role in AIDS.
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Among targets being addressed are Akt (protein kinase B, PKB); Angiopoietin-2; Aurora B (Aurora-1); Bcr-Abl; BRaf (B-Raf); c-Kit; Cyclin-dependent kinase 2 (CDK2); Cyclin-dependent kinase 7 (CDK7); Cyclin-dependent kinase 9 (CDK9); Delta-like 4 (DLL4); Epidermal growth factor (EGFr); focal adhesion kinase (FAK); HEr2/neu; Kinesin-like spindle protein (KSP)/Eg5; c-Kit; Lymphocyte-specific protein tyrosine kinase (Lck); Lyn; Hepatocyte growth factor receptor (HGFr)/c-Met; Notch 1 (TAN1); NF.

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