CCNA2

(redirected from cyclin-A2)

CCNA2

A gene on chromosome 4q25-q31 that encodes cyclin A2, which binds and activates CDC2 or CDK2 kinases, thus promoting both cell cycle G1/S and G2/M transitions.
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The membranes were probed using a primary antibody generated against one of the following proteins at the dilution indicated for each: cyclin-A2 (1:2000), cyclin-B1 (1:2000), caspase-3 (1:1000), caspase-7 (1:1000), and glyceraldehyde 3-phosphate dehydrogenase (GAPDH, 1 : 5000).
The accumulation of cyclin-A2 and -B1 in the HEC-1A and HEC-1B cells treated with AE-CA or CPT also suggested that a G2/M cell cycle arrest had occurred (Figure 3(d)).
Our western blotting analysis demonstrated the accumulation of cyclin-A2 and -B1 in both the CPT- and AECA-treated cells, which indicated that the biological activity of AE-CA and CPT in human endometrial carcinoma cells is approximately equivalent.