CCNE1

(redirected from cyclin Es)

CCNE1

A gene on chromosome 19q12 that encodes cyclin E1, which forms a complex with and acts as a regulatory subunit of CDK2. Cyclin E1 is required for cell cycle G1/S (start) transition; it accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. It is highly expressed in the testes and placenta.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
In addition, mRNA levels of cell cycle exit related genes, Rb, P21, P18, P19, P53, and P45, exhibited a significant increase; in contrast, the cell cycle genes, Cyclin D1, Cyclin D2, Cyclin E, CDK6, E2F1, and CDC20, were significantly decreased in FGF21 overexpression group (Figure 2(d)).