CCNE1

(redirected from cyclin E1)

CCNE1

A gene on chromosome 19q12 that encodes cyclin E1, which forms a complex with and acts as a regulatory subunit of CDK2. Cyclin E1 is required for cell cycle G1/S (start) transition; it accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. It is highly expressed in the testes and placenta.
Mentioned in ?
References in periodicals archive ?
The researchers showed that microRNA-503 reduces cell growth and prevents the formation of blood vessels by direct binding and inhibition of cyclin E1 and Cdc25 mRNA.
In fact, PPAR[delta] is frequently increased in thyroid tumors (benign and malignant), where it increases proliferation by inducing cyclin E1 (11).