CCNE1

(redirected from cyclin E1)

CCNE1

A gene on chromosome 19q12 that encodes cyclin E1, which forms a complex with and acts as a regulatory subunit of CDK2. Cyclin E1 is required for cell cycle G1/S (start) transition; it accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. It is highly expressed in the testes and placenta.
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It is under research that expression of RNA binding protein human antigen R (HuR) in breast cancer causes up-regulation of cyclin E1 but other researches show miR-16 represses cyclin E1.
Based on target prediction programs (miRTarBase, TargetScan, miRanda, and MiRBase) and published papers, we found highly evidenced candidate target genes (hypoxia-inducible factor 1A and Cullin 2 genes for hypoxia and angiogenesis; cyclin-dependent kinase 6 (CDK6), Cyclin D1 (CCND1), Cyclin E1 (CCNE1), and CCND3 genes for cell cycle) of hsa-miR-424-5p.
The researchers showed that microRNA-503 reduces cell growth and prevents the formation of blood vessels by direct binding and inhibition of cyclin E1 and Cdc25 mRNA.
In fact, PPAR[delta] is frequently increased in thyroid tumors (benign and malignant), where it increases proliferation by inducing cyclin E1 (11).