CCND3

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CCND3

A gene on chromosome 6p21 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. Cyclin D3 forms a complex with and is a regulatory subunit of CDK4 or CDK6, which are required for cell cycle G1/S transition. It also interacts with tumour suppressor protein Rb and is involved in its phosphorylation. The cyclin D3-CDK4 complex is involved in cell cycle progression through G2 phase into mitosis after UV light-induced damage.
References in periodicals archive ?
Several studies have shown that SOX11, (13, 14) cyclin D2, and/or cyclin D3 (15, 16) are positive in these cases.
Antiproliferative effects were associated with a G2/M cell cycle arrest and reduced protein expression of cyclin dependent kinases (CDK) 2, 4, 6, cyclin D3, and induced expression of cyclin-dependent kinase inhibitor 2C (p18) and 1A (p21).
1 These compounds down regulate the expressions of cdK2, cdK4, cyclin D1, cyclin D3, inhibit Tumour Necrosis Factor (TNF) induce COX-2 expression and activate the transcription factor NFKB.
For example, in the inducible model no changes were detected in cyclin D1 and p21 but in cyclin D3.
Requirement for cyclin D3 in lymphocyte development and T cell leukemias.
Shirley, MA Cyclin D3 MGC nucleus Mouse MCA1866; 1:40 Serotec, Raleigh, NC DAPI Nucleus H-1200; Vector 1.
Fiaschi-Taesch, and the team discovered that combining elevated amounts of the regulatory molecules cdk4 or cdk6 with a variety of D-cyclin proteins, particularly cyclin D3, stimulates human beta cell replication in test tubes.
GNI researchers discovered that PFTK1 specifically interacted with cyclin D3 (CCND3) and formed a tri-molecular complex with the cell cycle inhibitor p21, a key tumor suppressor whose mutations are frequently found in many forms of human cancer.
7) The cyclin D1-negative cases are usually positive for cyclin D2 or cyclin D3, which are occasionally expressed in other B-cell lymphomas, limiting the diagnostic usefulness of these studies.