Next-generation sequencing was performed on the biopsied tissue, gene mutations were found on Cyclin D2
( CCND2 ) at c.721-110A>C, epidermal growth factor receptor( EGFR ) at c.1298+722C>A and notch homolog 1 ( NOTCH1 )at c.4571C>T; and mutation frequencies were 7.1%, 4.3%, and 0.5%, respectively.
Tang, "MiR-30a upregulates BCL2A1, IER3 and cyclin D2
expression by targeting FOXL2," Oncology Letters, vol.
Several studies have shown that SOX11, (13, 14) cyclin D2
, and/or cyclin D3 (15, 16) are positive in these cases.
Targeted expression of cyclin D2
results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice.
In addition, mRNA levels of cell cycle exit related genes, Rb, P21, P18, P19, P53, and P45, exhibited a significant increase; in contrast, the cell cycle genes, Cyclin D1, Cyclin D2
, Cyclin E, CDK6, E2F1, and CDC20, were significantly decreased in FGF21 overexpression group (Figure 2(d)).
Transgenic mice with cardiac-specific overexpression of miR-204 showed an increase of CM proliferation throughout the embryonic and adult stages, which was associated with upregulated cell cycle regulators Cyclin A, Cyclin B, Cyclin D2
, Cyclin E, CDC2, and PCNA .
applied intermittent hypoxia and observed a significant elevation of [beta] cell proliferation both in vitro and in vivo, which coincided with increased cyclin D2
translocation to the nucleus.
Transcription factor 4(TCF4), zinc finger E-box binding homeobox 1 (ZEB1), and cyclin D2
(CCND2) were the genes found to be most influenced by these miRNAs.
Symbol Gene name 1 CCNA1 Cyclin A1 2 CCNA2 Cyclin A2 3 CCNB1 Cyclin B1 4 CCND1 Cyclin D1 5 CCND2 Cyclin D2
6 CCND3 Cyclin D3 7 CCNE1 Cyclin E1 8 CCNE2 Cyclin E2 9 CCNH Cyclin H 10 CDC25A Cell division cycle 25 homolog A (S.
For example, one risk variant is located near CCND2, the gene encoding cyclin D2
, a member of the cyclin family of proteins that regulate the cell cycle.
Mice deficient in the gene encoding cyclin D2
shows reduced [beta]-cell mass and hyperglycemia within three months of age.