CCND2

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CCND2

A gene on chromosome 12p13 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. Cyclin D2 forms a complex with and is a regulatory subunit of CDK4 or CDK6, which are required for cell cycle G1/S transition; it is thought to play a central role in germ cell proliferation. Cyclin D2 interacts with tumour suppressor protein Rb and is involved in its phosphorylation.

Molecular pathology
CCND2 is overexpressed in ovarian and testicular tumours.
References in periodicals archive ?
Importantly, neither cyclin D2 nor cyclin D3 is specific for MCL, (17) but nuclear expression of SOX11 is a specific marker associated with MCL, according to Chen et al (18) (Figure 1, B and C).
Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice.
Mutations that shortened the length of CCND2 were clustered around one end of the protein, the C-terminus, and resulted in stabilization of cyclin D2 and cell cycle activation, said Zhang, chair of the St.
Transcription factor 4(TCF4), zinc finger E-box binding homeobox 1 (ZEB1), and cyclin D2 (CCND2) were the genes found to be most influenced by these miRNAs.
For example, one risk variant is located near CCND2, the gene encoding cyclin D2, a member of the cyclin family of proteins that regulate the cell cycle.
Mice deficient in the gene encoding cyclin D2 shows reduced [beta]-cell mass and hyperglycemia within three months of age.
The c-Myc proto-oncogene is involved in transformation and cell proliferation partly through activation of cyclin D2 promoter and also induces programmed cell death which is mediated by nuclear respiratory factor 1 (NRF-1) and the Arf-p53 pathway (Luo et al.
Western blotting was used for determining specific protein levels associated with cell cycle (chk2, p53, p21, pl6, cdk6, cyclin D2 and cyclin E) and apoptosis (Bax, Bcl-2, Bcl-xl/xs, cytochrome c, caspase-9, -3.
However, for genes with very weak LD, such as cyclin D2 (CCND2; Figure 5B), many more sites will be required for a genetic association study because few sites within this gene are correlated.
7) The cyclin D1-negative cases are usually positive for cyclin D2 or cyclin D3, which are occasionally expressed in other B-cell lymphomas, limiting the diagnostic usefulness of these studies.
6A) showed that cyclin D2, cyclin A, cyciin B1, Cdk1 (Cdc2), and PCNA in MCF-7 cells were time-dependently down-regulated by taiwanin A, whereas the protein level of phospho-Cdk1 increased.