cyclin D1


Also found in: Wikipedia.

cyclin D1

A 36-kD protein which regulates cyclin-dependent protein kinase activity in G1 of the cell cycle. As a proto-oncogene, it activates cell-cycle progression, and is implicated in the pathogenesis of parathyroid and other neoplasms.

Molecular pathology
Cyclin-D1 overexpression is due to bcl-1 rearrangement, t(11;14)(q13;q32), and is activated by chromosome inversion, which places it under the influence of the regulatory region of the PTH gene.

Abnormal expression
Cyclin D1 is not expressed in normal or reactive lymphoid tissues. It is overexpressed in parathyroid adenoma, some breast cancers, squamous cell carcinoma of head and neck, and mantle zone lymphoma, but less commonly in other lymphomas.
References in periodicals archive ?
In estrogen receptor-positive (ER+) breast cancer cell lines, cyclin D1 and CDK4 & 6 promote phosphorylation of the retinoblastoma protein (Rb), cell cycle progression, and cell proliferation.
Molecular analysis shows that Ki67 expression and low cyclin D1 immuno-histological expression is linked to higher risk of recurrence in children but p27Kip1 expression and p53 over-expression is not associated with higher rate of recurrence.
Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons.
In contrast to cyclin E1 expression, the analysis showed that expression of cyclin D1, the molecular partner of CDKs 4 and 6 which are the targets of palbociclib, or PI3 kinase, or PIK3CA, mutations were not predictive of efficacy for palbociclib plus hormone therapy.
In the breast cancer cell line, TNF-[alpha] increases cell proliferation through increased NF-[kappa]B caused byincreased cyclin D1 expression.
Those lymphoma cells expressed diffuse positive immunohistochemical stain for CD20, CD79a, CD5, and cyclin D1, but were negative for CD10, CD23, BCL6, and MUM1.
Replication Untreated cells 1 1 Vanadyl sulphate treated cells 0 0 Cyclin D1 1.
This led to the breakdown of the complex formed between CDKs and cyclin D1 and E and decreased phosphorylation inactivation of tumor suppressor protein Rb1.
(1) The genetic hallmark of this lymphoma, considered to be the primary genetic event, is the t(11;14)(q13;q32) translocation between the immunoglobulin H (IgH) gene and the cyclin D1 gene (CCND1), leading to overexpression of the cyclin D1 protein, which is easily detected by immunohistochemistry.
In estrogen receptor-positive breast cancer cell lines, cyclin D1 and CDK4 and 6 promote phosphorylation of the retinoblastoma protein, cell cycle progression, and cell proliferation.
Activation of cyclin D1 and CDK4/6 plays a significant role in the tumorigenesis of HR+/HER2+ breast cancer [37, 76, 84].