cyclin


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Related to cyclin: Cyclin d1, Cyclin dependent kinase, cyclin B1

cy·clin

(sī'klin),
A class of proteins involved in regulation of the cell cycle.

cyclin

(sī′klĭn)
n.
Any of a class of proteins that fluctuate in concentration at specific points during the cell cycle and that regulate the cycle by binding to a kinase.

cyclin

[sī′klin]
one of a class of intracellular proteins that appear during the eukaryotic cell cycle. The cyclin concentration increases during the cycle until halfway to the mitosis stage, when it drops to zero. Cyclin may act as a molecular switch that activates mitosis when its concentration reaches a certain point.

PCNA

A gene on chromosome 20pter-p12 that encodes a homotrimeric nuclear protein that is a cofactor of DNA polymerase delta. PCNA is ubiquinated in response to DNA damage and is involved in RAD6-dependent DNA repair.
References in periodicals archive ?
Correlation of cyclin D1 expression with aggressive DNA pattern in patients with tobacco-related intraoral squamous cell carcinoma.
Cyclin G, bcl2 and p21 expressions failed to respond to any treatment in both cell types (data not shown).
1] phase in gastric cancer cells by modulation of regulatory proteins such as Rb and cyclin D1 (Jeong et al.
Immunohistochemistry for cyclin D1: The cyclin D1 expression was studied in formalin-fixed and paraffin embedded tumour samples by the standard immunohistochemical technique on 5 micron paraffin sections using Streptavidin--biotin Universal Detection system (Immunotech, France).
The Ki-67 index and immunoreactivity for Skp2, p27, and cyclin D1 were determined in each case.
Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts--a possible mechanism for arsenite's comutagenicity.
Most advanced is CYC202, a Cyclin Dependent Kinase (CDK) inhibitor, in Phase II trials for breast and lung cancer.
This gene encodes a protein called cyclin dependent kinase 1, or CDK 1.
Although abemaciclib inhibits both CDK 4 and CDK 6, the results from the cell-free enzymatic assays have shown that it was most active against Cyclin D 1 and CDK 4.
Chrysin plays an important role in the prevention of the growth of cancer cells, and it reduces the cyclin D1 gene.
Equal amounts of cell protein (40 [micro]g) were separated by SDS-PAGE and analyzed by Western blot using specific antibodies to Wnt7a, Wnt5a, GSK3[beta], [beta]-catenin, cyclin D1, Caspase-3 and [beta]-actin (as a loading control).