Table 4: Percentage of Cells Expressing Cyclins
and CDKIs, According to Phase G0/G1 Cyclin
E p21 p16 CML 26 21.
Correlation of cyclin
D1 expression with aggressive DNA pattern in patients with tobacco-related intraoral squamous cell carcinoma.
G, bcl2 and p21 expressions failed to respond to any treatment in both cell types (data not shown).
1] phase in gastric cancer cells by modulation of regulatory proteins such as Rb and cyclin
D1 (Jeong et al.
Immunohistochemistry for cyclin
D1: The cyclin
D1 expression was studied in formalin-fixed and paraffin embedded tumour samples by the standard immunohistochemical technique on 5 micron paraffin sections using Streptavidin--biotin Universal Detection system (Immunotech, France).
The Ki-67 index and immunoreactivity for Skp2, p27, and cyclin
D1 were determined in each case.
Effects of arsenite on p53, p21 and cyclin
D expression in normal human fibroblasts--a possible mechanism for arsenite's comutagenicity.
Most advanced is CYC202, a Cyclin
Dependent Kinase (CDK) inhibitor, in Phase II trials for breast and lung cancer.
This gene encodes a protein called cyclin
dependent kinase 1, or CDK 1.
Although abemaciclib inhibits both CDK 4 and CDK 6, the results from the cell-free enzymatic assays have shown that it was most active against Cyclin
D 1 and CDK 4.
Chrysin plays an important role in the prevention of the growth of cancer cells, and it reduces the cyclin
Equal amounts of cell protein (40 [micro]g) were separated by SDS-PAGE and analyzed by Western blot using specific antibodies to Wnt7a, Wnt5a, GSK3[beta], [beta]-catenin, cyclin
D1, Caspase-3 and [beta]-actin (as a loading control).