APL-2 is a synthetic cyclic peptide
conjugated to a polyethylene glycol polymer that binds specifically to C3 and C3b, effectively blocking all three pathways of complement activation (classical, lectin, and alternative).
The group identified a cyclic peptide
that could bind to hair under shampooing conditions, which meant a low pH and in the presence of surfactants.
In a two-step process high target affinity and bioavailability are installed:1) Peptide macrocyclization for the stabilization of the irregular bioactive secondary structure2) Evolution of the cyclic peptide
into a bioavailable macrocyclic compoundUsing a well-characterized model system developed in my lab, initial design principles will be elucidated.
Among poor sleepers, a higher proportion of patients tested positive for rheumatoid factor and anti-citrullinated cyclic peptide
Facile synthesis of orthogonally protected amino acid building blocks for combinatorial N-backbone cyclic peptide
Some rrs mutations also confer resistance to the cyclic peptide
antibiotic CAP .
In our study, the cyclic peptide
, Pep42, CTVALPGGYVRVC, was selected for its ability to target and internalize within the Glucose Regulated Protein 78 (GRP78) harboring tumor cell lines.
Chemicals called cyclic peptide
inhibitors can stop sweet-toothed cancer cells from growing.
mMass as a software tool for the annotation of cyclic peptide
tandem mass spectra.
In addition, during the quarter, Janssen-Cilag GmbH completed the acquisition of CorImmun GmbH, a privately held drug development company in Germany, with lead compound, COR-1, a small cyclic peptide
, currently in early clinical development for the treatment of heart failure.
Cyclosporin A (CsA) is a 1202 Da cyclic peptide
, widely used for preventing organ rejection following transplants.
Isolation, structural characterization, and properties of mattacin (polymyxin M), a cyclic peptide
antibiotic produced by Paenibacillus kobensisM.