APL-2 is a synthetic cyclic peptide
conjugated to a polyethylene glycol (PEG) polymer that binds specifically to C3 and C3b, effectively blocking all three pathways of complement activation (classical, lectin, and alternative).
APL-9, an investigational drug, is a pegylated synthetic cyclic peptide
designed to modulate the complement cascade centrally at C3.
Khazanovich, "Self-assembling organic nanotubes based on a cyclic peptide
architecture," Nature, vol.
CP1: Fmoc-protecting group of Fmoc-Leu-NH-SAL-Trt(2-Cl)-resin (500 mg, 0.43 mmol) was deprotected by treatment with 20% piperidine in DMF.
To improve the stability of iCREKA in the blood, the 2 terminal cysteine (Cys) residues in the homing peptide and the membrane-penetrating peptide were covalently linked via a disulfide bond, forming a cyclic peptide
. In addition, a lysine residue was added to the C-terminus of the cyclic peptide
, which was used for fluorescein or radionuclide labeling.
The group identified a cyclic peptide
that could bind to hair under shampooing conditions, which meant a low pH and in the presence of surfactants.
Among poor sleepers, a higher proportion of patients tested positive for rheumatoid factor and anti-citrullinated cyclic peptide
0-Defensins are naturally expressed in Old World monkeys and are the only cyclic peptide
identified in mammals .
Tan, "Selection of high affinity ligands to hepatitis B core antigen from a phage-displayed cyclic peptide
library," Journal of Medical Virology, vol.
Although the cyclic NGR binds with higher affinity than linear NGR, and drug conjugates with the cyclic peptide
have 10-fold greater antitumor efficacy, the linear NGR has been the preferred ligand on the surface of nucleic acid carriers because it avoids cysteine bridges that may occur between different carrier molecules.
Figures 1 represent only results derived from the three methods for the detection of cyclic peptide
hepatotoxin genes by using HEPF and HEPR primers was developed to identify potentially microcystin or nodularin in two genus of cyanobacteria.
Facile synthesis of orthogonally protected amino acid building blocks for combinatorial N-backbone cyclic peptide